SPIONs as Nano-Theranostics Agents (eBook)

Ms. Atefeh Zarepour received her B.S. in genetic engineering in 2011 and her M.S. degree in Nanobiotechnology in 2014 from University of Isfahan. She is currently a Ph.D. student under the guidance of Prof. Ali Zarrabi in Nanobiotechnology at University of Isfahan. Her researches are focused on SPIONs and Graphene Oxide, their surface modification with different biocompatible polymers to regulate the biological properties of nanoparticles and nanoparticle-based drug delivery systems and their applications as nano-theranostics.Dr. Ali Zarrabi received his Ph.D. from Sharif University of Technology, Tehran, in Chemical Engineering. In 2011, he joined the Department of Biotechnology, University of Isfahan, as an Assistant Professor. His current research interests include Nanobiotechnology, Nanomedicine, Drug Delivery Systems, Nanomaterials, SPIONs and Surface Modifications. Dr. Zarrabi has been a member of American Chemical Society (ACS), British Society for Nanomedicine, European Society for Nanomedicine, American Association for the Advancement of Science (AAAS), Nanotechnology Strategic Committee, University of Isfahan, Biotechnology Strategic Committee, University of Isfahan, Talented Students Committee, University of Isfahan, Iranian Genetic Society and Iran Nanotechnology Initiative.Dr. Arezoo Khosravi is an Assistant Professor in the Department of Mechanical Engineering of Islamic Azad University of Khomeinishahr in Isfahan, Iran. She completed her Ph.D. of nanotechnology at Sharif University of Technology and her M.Sc. study at Tarbiat Modares University. Her research interests lie in the area of the nanomaterial synthesis and their applications in several fields such as bio-processes, drug delivery, oil and petroleum engineering and also energy conversion.

Contents 6
Abbreviations 7
List of Figures 9
1 SPIONs as Nano-Theranostics Agents 10
1.1 Introduction 10
1.2 Iron Oxide Nanoparticles 12
1.2.1 Properties of Magnetic Nanoparticles 12
1.2.1.1 Magnetic Behavior 12
1.2.1.2 Size 13
1.2.1.3 Charge 14
1.2.1.4 Surface Functionality and Colloidal Stability 14
1.2.2 Methods of Preparation 15
1.2.2.1 Copercipitation 15
1.2.2.2 Sol-Gel 15
1.2.2.3 Thermal Decomposition 15
1.2.2.4 Polyol 16
1.2.2.5 Sonolysis 16
1.2.2.6 Hydrothermal 16
1.2.2.7 Microemulsion 16
1.2.2.8 Green Synthesis 16
1.2.2.9 Other Methods 17
1.3 Biomedical Applications 17
1.3.1 Biological Applications 17
1.3.1.1 Tissue Engineering 17
1.3.1.2 Magnetic Separation 18
1.3.1.3 Toxin Decorporation 19
1.3.1.4 Virus and Bacterial Separation 20
1.3.1.5 Protein and Nucleic Acid Separation 20
1.3.1.6 Enzyme Immobilization 21
1.3.1.7 Cell Labeling and Separation 21
1.3.2 Theranostics and Nano-Theranostics Applications of SPIONs 22
1.3.2.1 Theranostics and Nano-Theranostics 22
1.3.2.2 Diagnosis 23
Magnetic Resonance Imaging (MRI): Principles and Applications 24
Multimodal Imaging 26
1.3.2.3 Therapy 28
Hyperthermia 28
Drug and Gene Delivery 29
Targeting Approaches 30
Surface Functionalization 32
Other Therapy 34
1.3.2.4 SPIONs Based Nano-Theranostics for Cancer Therapy 35
1.3.2.5 SPIONs Based Nano-Theranostics for Inflammation, Neurodegenerative and Autoimmune Disease 37
1.4 Challenges and Future Prospects 38
References 40