Non-canonical Cyclic Nucleotides

Part I: 3',5'-cCMP and 3',5'-cUMP as second messengers: cCMP and cUMP across the tree of life: From cCMP and cUMP generators to cCMP- and cUMP-regulated cell functions.- cCMP and cUMP in apoptosis: Concepts and methods.- Mammalian nucleotidyl cyclases and their nucleotide binding sites.- The Pseudomonas aeruginosa exoenzyme Y: A promiscuous nucleotidyl cyclase edema factor and virulence determinant.- Cyclic nucleotide monophosphates in plants and plant signalling.- cAMP-dependent protein kinase and cGMP-dependent protein kinase as cyclic nucleotide effectors.- Regulation of HCN ion channels by non-canonical cyclic nucleotides.- Identification of cCMP and cUMP substrate proteins and cross-talk between cNMPs.- Inactivation of non-canonical cyclic nucleotides: Hydrolysis and transport.- Part II: 3',5'-cIMP, 8-nitro-cGMP, 2',3'-cNMPs and cyclic dinucleotides as signaling molecules: 3',5'-cIMP as potentialsecond messenger in the vascular wall.- The discovery of 2',3'-cNMPs in mammalian systems: From rodents to humans.- 8-Nitro-cGMP: A novel protein-reactive cNMP and its emerging roles in autophagy.- Cyclic dinucleotides in the scope of the mammalian immune system.- Part III: Methods/Tools for cNMP research: Mass-spectrometric analysis of non-canonical cyclic nucleotides.- Medicinal chemistry of the noncanonical cyclic nucleotides cCMP and cUMP.- Holistic methods for the analysis of cNMP effects.- The chemistry of the non-canonical cyclic dinucleotide 2'3'-cGAMP and its analogs.