SUMO Regulation of Cellular Processes -

SUMO Regulation of Cellular Processes

Van G. Wilson (Herausgeber)

Buch | Hardcover
VIII, 415 Seiten
2017 | 2nd ed. 2017
Springer International Publishing (Verlag)
978-3-319-50043-0 (ISBN)
181,89 inkl. MwSt
This review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. The first book to cover this subject, each chapter covers the role of sumoylation in fundamental biochemical activities.

This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule.

Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.

The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria.

Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research.

This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Preface.- Introduction to Sumoylation.- Part I Molecular Functions.-  Roles of Sumoylation in mRNA Processing and Metabolsim.- SUMO and Chromatin Remodeling.- Functions of SUMO in the Maintenance of Genome Stability.- Regulation of Cellular Processes by SUMO: Understudied Topics.- The Molecular Interface Between The SUMO And Ubiquitin Systems.- . SUMO and Nucleocytoplasmic Transport.- SUMO Modification of Ion Channels.-  The Roles of SUMO in Metabolic Regulation .- Part II Cell Growth Regulation.- The SUMO Pathway in Mitosis.-  Wrestling with Chromosomes: The Roles of SUMO During Meiosis.- Sumoylation in Development and Differentiation.- The Role of Sumoylation in Senescence.- Regulation of Plant Cellular and Organismal Development by SUMO.- SUMO in Drosophila Development.- Part III Diseases.- SUMOylation: Implications for Neurodegenerative Diseases.- Sumoylation and Its Contribution to Cancer.- Sumoylation Modulates the Susceptibility to Type 1 Diabetes.-  Sumoylation in Craniofacial Disorders.- Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases.-  Viral Interplay with the Host Sumoylation System.- SUMOylation as an Integral Mechanism in Bacterial Infection and Disease Pathogenesis.- Index.

Erscheinungsdatum
Reihe/Serie Advances in Experimental Medicine and Biology
Zusatzinfo VIII, 415 p. 41 illus., 26 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Zellbiologie
Schlagworte biochemistry • Biomedical and Life Sciences • Biomedicine general • Cell Biology • cellular biology (cytology) • cellular processes • DNA • Medical Research • Molecular mechanisms • Post-translational modification • Posttranslational modification • Protein Biochemistry • Protein Science • Regulation • Sumoylation • Translation • Ubc9
ISBN-10 3-319-50043-0 / 3319500430
ISBN-13 978-3-319-50043-0 / 9783319500430
Zustand Neuware
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