Gastrin

A comprehensive reference on the gastrointestinal hormone, gastrin. Topics include gastrin's molecular biology and its major receptor, and its role in diseases such as peptic ulcers and different cancers. The book also presents research findings, and addresses clinical issues like drug effects.

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This volume is a comprehensive reference on the important gastrointestinal hormone gastrin. Leading investigators examine the molecular biology of gastrin and its major receptor; the physiology of gastrin as a hormone regulating gastric secretion and cell growth; the role of gastrin in peptic ulcer disease, endocrine hyperplasia, and gastric carcinoid tumour formation; and the potential of gastrin to act as a growth-promoting agent in colon cancer and small cell lung carcinoma. Important research findings presented included a description of the primary amino acid structure of the gastrin receptor and a study of the histamine-releasing activity of gastrin. Clinical issues addressed include the effects and potential side effects of drugs that eliminate gastric acid secretion; the differential diagnosis and significance of hypergastrinemia (including hypergastrinemia in Helicobacter pylori gastritis); and the diagnosis and management of gastrinomas.