Handbook of Experimental Pharmacology / Cytochrome P450

This volume describes and analyzes the enzyme system cytochrome P450, exploring the reaction mechanisms involved and the evolution and nomenclature of this superfamily. It also defines the hepatic microsomal enzyme in a large number of species, from mammals to birds and fish.

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In this volume are collected a variety of investigations on the cytochrome P450 superfamily, in order to present complete coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature of this superfamily of enzymes. They also describe the hepatic microsomal enzyme in a large number of species, from mammals, birds and fish to plants and unicellular organisms. The different P450 forms in different tissues of the mammalian system are also treated. Regulatory factors of P450 expression receive considerable attention, as do studies on the mechanism of interaction of the microsomal monooxygenase system components. Of particular interest is a series of chapters dedicated to forms of cytochrome P450 involved in steroid hormone biosynthesis.