Membrane Defenses Against Attack by Complement and Perforins

In this volume a comprehensive review of membrane proteins that regulate complement and perforin-mediated cytolysis is presented. A detailed analysis is provided of the biochemical, molecular, and functional features of these proteins.

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In this volume a comprehensive review of membrane proteins that regulate complement and perforin-mediated cytolysis is presented. A detailed analysis is provided of the biochemical, molecular, and functional features of these proteins. The glycosyl-phosphatidyl-inositol linked proteins are covered, with emphasis placed on the functional importance of this type of membrane anchor. Further chapters include reviews of the effects of complement activation on cells that are metabolically active, and of the regulation of cell killing by cytotoxic lymphocytes, considering the similarities and disparities between the complement and perforin systems. The therapeutic use of recombinant CRI for immune-mediated pathophysiological processes is discussed in a separate section.