Application of Basic Science to Hematopoiesis and Treatment of Disease

A volume in which leading international investigators explore potential applications of basic science to haematopoiesis and treatment of cancer and other diseases. It includes reviews of relevant research findings, and descriptions of several emerging clinical appplications of this research.

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In this volume, leading international investigators explore potential applications of basic science to haematopoiesis and treatment of cancer and other diseases. The first three sections review relevant research findings on the molecular control of cellular differentiation and on normal and disordered haematopoiesis. Topics covered include haematopoietic growth factors and their receptors; genes in early haematopoiesis; stem cell development; structure and activation of the erythropoietin receptor; oncogenes related to haematopoietic malignancy; the biology of chronic myelogenous leukaemia; and the biology of interleukin-6. The final section describes several emerging clinical applications of this research, such as clinical use of cytokines, tolerance induction with monoclonal antibodies, and gene transfer into haematopoietic stem cells.