Angiogenesis and Anti-Angiogenesis in Hematological Malignancies - Domenico Ribatti

Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

Buch | Softcover
114 Seiten
2016 | Softcover reprint of the original 1st ed. 2014
Springer (Verlag)
978-94-024-0305-3 (ISBN)
119,99 inkl. MwSt
Exploring the critical role of angiogenesis in tumor progression and metastasis, this book features the latest and most promising anti-angiogenesis molecules now being deployed in the battle against hematological malignancies such as leukemia and lymphoma.
It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

Preface.- Introduction.- Angiogenesis in multiple myeloma.- Angiogenesis in lymphomas.- Angiogenesis in leukemia.- Antiangiogenesis.- Concluding remarks.- References.

Erscheinungsdatum
Zusatzinfo 30 Illustrations, color; 14 Illustrations, black and white; XI, 114 p. 44 illus., 30 illus. in color.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Hämatologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie
ISBN-10 94-024-0305-1 / 9402403051
ISBN-13 978-94-024-0305-3 / 9789402403053
Zustand Neuware
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