Ocular Periphery and Disorders

Dr. D’Amore earned her PhD in Biology from Boston University, was a postdoctoral fellow in Biological Chemistry and Ophthalmology at Johns Hopkins Medical School, then moved to Boston Children’s Hospital as Assistant Professor where she remains Research Associate in Surgery. In 1998, she became Charles L. Schepens Professor of Ophthalmology and Professor of Pathology at Harvard Medical School and a Senior Scientist at Mass. Eye and Ear. She is the Associate Chief of Basic and Translational Research for Ophthalmology at Mass. Eye and Ear and the Vice Chair of Basic and Translational Research for the Department of Ophthalmology. Dr. D’Amore is an international expert in vascular growth and development and has been at the forefront of angiogenesis research for over three decades. She has published more than 170 peer-reviewed papers, 75 reviews, and edited or co-edited two books. In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.

I. Anatomy and Pathophysiology of Blinking and Eye Movements Eyelid anatomy and the pathophysiology of blinking Differentiation and morphogenesis of extraocular muscles Extraocular muscle anatomy Extracocular muscle metabolism Extraocular muscles: proprioception and proprioceptors Abnormal eye movements due to disease of the extraocular muscles and their innervation Extraocular muscles: functional assessment in the clinic

II. Structure and Function of the Tear Film, Ocular Adnexa, Cornea, and Conjunctiva in Health and Pathogenesis in Disease Meibomian glands and lipid layer Lacrimal gland overview Lacrimal gland hormone regulation Lacrimal gland signaling-neural Lids: Anatomy, pathophysiology, and mucocutaneous junction Ocular surface-overview of electrolyte and fluid transport across the conjunctiva Conjunctival Goblet cells Ocular mucins Tear drainage Cornea overview Corneal epithelium-cell biology and basic science Corneal nerves-anatomy Corneal nerves-function Corneal epithelium-wound healing junctions, attachment to stroma receptors, matrix metalloproteinases, intercellular communications Corneal epithelium-transport and permeability Stem cells of the ocular surface The ocular surface-the surgical treatment for corneal epithelial stem cell deficiency, corneal epithelial defects, and periferal corneal ulcer Refractive surgery Refractive surgery and inlays Contact lenses Imaging of the cornea The corneal stroma Corneal dystrophies Corneal imaging-clinical Corneal scars Corneal endothelium-overview Regulation of corneal endothelial function Regulation of corneal endothelial cell proliferation Artificial cornea Drug delivery to cornea and conjunctiva-esterase- and protease-directed prodrug design Knock-out mice models: cornea, conjunctiva, eyelids, and lacrimal glands Gene therapy

III. Immune Regulation of the Cornea and Conjunctiva and Its Dysregulation in Disease Adaptive Immune System and the Eye: Mucosal Immunity Adaptive immune system and the eye: T-cell mediated immunity Innate immune system and the eye Immunoregulatory processes that sustain immune privilege in the eye Immunosupressive and anti-inflammatory molecules that maintain immune previlege of the eye Antigen-presenting cells in the eye and ocular surface Dry eye: An immune-based inflammation Penetrating keratoplasty Immunopathogenesis of HSV Keratitis Immunopathogenesis of Onchocerciasis (River Blindness) Immunopathogenesis of pseudomonas keratitis Immunobiology of acanthomeba karatitis Molecular and cellular mechanisms in allergic conjunctivitis Pathogenesis of fungal keratitis Conjunctiva Immune surveillance Defense mechanisms of tears and ocular surface Corneal epithelium- response to infection Inflammation of the Conjunctiva Concept of Angiogenic Privilege Corneal angiogenesis Avascularity of the cornea

IV. Visual Acuity Related to the Cornea and Its Disorders Visual optics: pupil Acuity Contrast sensitivity Astigmatism Vera-Diaz- Myopia Levi-Amblyopia Harb- Hyperopia