Nuclear Hormone Receptors

An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.

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Nuclear hormone receptors include those which recognize thyroid and steroid hormones, vitamin D and retinoic acid. Together they form a supergene family characterized by their ability to bind both ligands and the genes which respond to those ligands. "Nuclear Hormone Receptors" an overview of this supergene family and contains up-to-date accounts of the structure of these receptors and the genes which encode them. It also covers their interaction with DNA recognition sites, chromatin and transcription factors, the mechanisms by which they regulate gene expression during cell growth, development and differentiation, and defective receptors involved in endocrine-related including cancer.
The book is illustrated and fully referenced and cross indexed and is intended to be of use to molecular biologists (offering them detailed descriptions of the best characterized mediators of eukaryotic gene regulation), endocrinologists (offering them an explanation of the mechanisms by which hormones mediate cellular responses), pharmacologists (who are presented with the biochemical action of hormones) and clinicians, for whom the importance of these receptors in deficiences and cancer is demonstrated.