Ras Superfamily Small G Proteins: Biology and Mechanisms 1
Springer Wien (Verlag)
978-3-7091-1988-4 (ISBN)
Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
lt;p>Evolution of the Ras Superfamily of GTPases.- The structure of the G domain of the Ras superfamily.- GEFs and GAPs: Mechanisms and Structures.- Bacterial protein toxins acting on small GTPases.- Posttranslational modifications of small G proteins.- Targeting the Raf-MEK-ERK Mitogen-Activates Protein Kinase Cascade for the Treatment of RAS Mutant Cancers.- RAS Genes and Cancer.- The Spatial Organization of Ras Signaling.- Ras Nanoclusters.- Mouse Models of Ras induced Tumors and Developmental Disorders.- Rap signaling.- The coordinated biology and signaling partners of Ral G-proteins.- Structure and Function of the mTOR Activator Rheb.- Classical Rho proteins: Biochemistry of molecular switch function and regulation.- Atypical Rho family members.- Molecular Structures, Cellular Functions and Physiological Roles of Rho Effectors.- Principles driving the spatial organization of Rho GTPase signaling at synapses.- Rho GTPases in Cancer.
Erscheinungsdatum | 29.08.2016 |
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Zusatzinfo | XIV, 445 p. 85 illus., 83 illus. in color. |
Verlagsort | Vienna |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Schlagworte | biochemistry • Biomedical and Life Sciences • Cell Biology • cell signaling • cellular biology (cytology) • GTPases, GTP-binding • Molecular Switch • protein imaging • Protein Science • Protein Structure • spatiotemporal regulation • vesicular traffic |
ISBN-10 | 3-7091-1988-X / 370911988X |
ISBN-13 | 978-3-7091-1988-4 / 9783709119884 |
Zustand | Neuware |
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