Stem Cell-Derived Models in Toxicology
Humana Press Inc. (Verlag)
978-1-4939-6659-2 (ISBN)
Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
Stem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space”.- Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk.- Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology.- Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes.- The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential.- Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions.- HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems.- Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes.- Decoding Ca2+ Signals as a Non-Electrophysiological Method forAssessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes.- Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes.- Edge Detection for Contractility Measurements with Cardiac Spheroids.- Contractile Force Readout of hESC-Cardiomyocytes.- In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models.- Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes.- Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA).- Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies.
Erscheinungsdatum | 05.01.2017 |
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Reihe/Serie | Methods in Pharmacology and Toxicology |
Zusatzinfo | 108 Illustrations, color; 16 Illustrations, black and white; XII, 341 p. 124 illus., 108 illus. in color. With online files/update. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Schlagworte | cardiomyocytes • Cardiotoxicity • drug development • Hepatotoxicity • neurotoxicity • Pluripotent stem cell models • Pre-clinical safety assessments • Stammzelle • Toxikologie |
ISBN-10 | 1-4939-6659-6 / 1493966596 |
ISBN-13 | 978-1-4939-6659-2 / 9781493966592 |
Zustand | Neuware |
Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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