Methylxanthines

From the contents: Brief history of methylxanthine use. Distribution of methylxanthines in plants with comments on possible evolutionary origins. Pharmakokinetics and metabolism of natural methylxanthines in animals and man. Phosphodiesterase inhibition. Ryanodine receptors and calcium. Adenosine receptor antagonism. Theobromine and the pharmacology of cocoa. Pentoxifylline. Propentofylline. Methylxanthines, seizures and excitotoxicity. Methylxanthines and neurodegenerative disease. Methylxanthines and pain. Methylxanthines during pregnancy and early postnatal life. Methylxanthines and sleep. Methylxanthines and the kidney. Cardiovascular effects of methylxanthines. Methylxanthines in asthma. Methylxanthine effects on inflammatory cells. Methylxanthines, inflammation and cancer. Methylxanthines and drug dependence. Methylxanthines and reproduction. Methylxanthines and human health. Epidemiological and experimental evidence.