Allosterism in Drug Discovery

Modulation of Biological Targets: Why Use Allosteric Ligands?;

Identifying and Quantifying Allosteric Drug Function;

Targeting Catalytic and Non-catalytic Functions of Protein Kinases;

Molecular Biology Techniques Applied to GPCR Allosteric and Biased Ligands;

Examining Allosterism in a Dimeric GPCR Context;

A Unifying Approach to the Duality of "Energetic" Versus "Conformational" Formulations of Allosteric Coupling: Mechanistic Implications on GPCR Allostery;

mGluR2 Positive Allosteric Modulators;

Muscarinic Receptors Allosteric Modulation;

Positive Allosteric Modulators of Opioid Receptors;

mGluR7 allostery: up and down modulation;

Allosteric Modulators of Adenosine, P2Y and P2X Receptors;

Positive Allosteric Modulators of G Protein-Coupled Receptors that Act via Covalent Mechanisms of Action;

mGluR4 PET ligands as enablers of target biology understanding;

Mechanism of action of a GluN2C- and GluN2D-selective NMDA receptor positive allosteric modulator;

Development of AMPA Receptor Modulators as Cognition Enhancers;

Allosteric modulation of the neuronal nicotinic acetylcholine receptor;

Allosteric Binding in the Serotonin Transporter – Pharmacology, Structure, Function and Potential Use as a Novel Drug Target;

Allosteric Inhibition of Abl Kinase;

Allosteric Modulators of Heat Shock Protein 90 (HSP90);

A look forward;