Introduction to Nanotheranostics (eBook)

Contents 6
Introduction 8
1 Introduction to Nanotheranostics 9
Abstract 9
1.1 Nanoparticles in General 9
1.1.1 Types of Nanoparticles 9
1.1.2 Importance of Coating or Surface Functionalization for Cellular Internalization 10
References 13
2 Metallic Nanoparticles for Theranostics 15
Abstract 15
2.1 Shape-Controlled Synthesis of Silver and Gold Nanoparticles 15
2.2 Antimicrobial Silver Nanoparticles 17
2.3 Gold Nanoparticles for SERS Detection and Drug Delivery 19
2.4 Effects of Surface Functionalization of Au NPs on Cell Delivery 20
2.4.1 Au–Herceptin Nanoclusters for Nuclear Targeting and Cancer Therapy 21
2.4.2 Au–Peptide NPs as Drug Delivery Vehicles 22
2.5 Silver Nanoparticles for Photo-Activated Gene Silencing 25
References 27
3 Semiconducting Nanoparticles or Quantum Dots for Theranostics 29
Abstract 29
3.1 Synthesis and Preparation 29
3.2 Applications of QDs 30
3.2.1 Intracellular Delivery of QDs 31
3.2.2 In Vivo Imaging with QDs 32
References 36
4 Magnetic Nanoparticles 39
Abstract 39
4.1 Introduction 39
4.2 Synthesis of MNPs 41
4.2.1 Co-precipitation 41
4.2.2 Micro-emulsions 43
4.2.3 Spray Pyrolysis 43
4.2.4 Polyols 43
4.2.5 Thermal Decomposition 44
4.2.6 Chemical Vapour and Plasma Assisted Synthesis 44
4.3 Stabilization of Magnetic Nanoparticles 45
4.3.1 Oxidation 45
4.3.2 Surfactant and Polymer Coating 46
4.3.3 Coating with Precious Metals 47
4.3.4 Silica Coating 47
4.3.5 Carbon Based Coating 49
4.3.6 Composites 51
4.4 Functionalization of the MNPs 56
4.5 Applications of MNPs 58
4.5.1 Non-biomedical Applications 58
4.5.2 Biomedical Applications 59
4.5.2.1 Gene Delivery in Cells Using MNPs 60
4.5.2.2 Drug Delivery 61
4.5.2.3 Magnetic Particles for Hyperthermia 62
4.5.2.4 Bio-imaging 65
References 67
5 Multifunctional Nanoparticles 77
Abstract 77
5.1 Other Nanoparticles for Nanotheranostics 79
5.2 Conclusions and Outlook 80
References 85