Sulphur Containing Drugs and Related Organic Compounds

This is the first volume in a new series designed to collate and review current knowledge concerning the chemical mechanisms of biotransformations and drug toxicity. The book deals with the importance and uses of sulphur xenobiotics and surveys the metabolism of inorganic sulphur compounds.

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This is the first volume in a new series of books designed to collate and critically review current knowledge concerning the chemical mechanisms of biotransformations and drug toxicity. It is a comprehensive three-volume work which organises all material on sulphur xenobiochemistry in a "library" of books which will be a standard reference source on the subject for many years to come. The first of these volumes, "Metabolism of Sulphur Functional Groups", is sub-divided into Parts A and B which together cover the chemical and biochemical reactivity of organic compounds with different types of sulphur functionalities, taking account of all the latest information from authoritative sources world-wide. Part A commences with an editorial introduction to the subject which both outlines the main features of the role of such organosulphur compounds in bio-chemical processes, and shows how research emphasis in recent years has shifted to exogenous synthetic compounds used in industry, agriculture and medicine. The book deals with the importance and uses of sulphur xenobiotics, and surveys the metabolism of inorganic sulphur compounds as well as thioethers, thiols and disulphides.
Part B takes up the chemical and mechanistic theme of Part A, discussing the processes involved in desulphuration of phosphothionates, thioamides and thiocarbamides. The authors then progress to an exposition of the further metabolism of sulphoxides, sulphones, sulphonamides and sulphonium compounds: and conclude with chapters reviewing metabolism of sulphur heterocycles and sulphur-containing secondary metabolites.