Thresholds of Genotoxic Carcinogens (eBook)

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. - Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens - Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens - Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation - Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation

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Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. - Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens- Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens- Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation- Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation