DNA Repair in Cancer Therapy

Molecular Targets and Clinical Applications

Mark R. Kelley (Herausgeber)

Buch | Softcover

330 Seiten

2016
Academic Press Inc (Verlag)
978-0-12-810360-9 (ISBN)

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DNA Repair in Cancer Therapy

Mark R. Kelley, Melissa L. Fishel

2016

Buch | Hardcover

138, ⁴⁰ €

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Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), other approaches have focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA that primarily results from the front-line cancer treatments; chemotherapy and radiation.

This comprehensive and timely reference focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

Mark R. Kelley, PhD is currently the Betty and Earl Herr Chair in Pediatric Oncology Research, Associate Director for the Herman B Wells Center for Pediatric Research, and the Associate Director of Basic Science Research at the IU Simon Cancer Center. Dr. Kelley’s laboratory studies DNA base excision repair in normal and tumor cells, including the study of DNA repair genes in cognitive dysfunction and peripheral neuropathy. He holds 10 patents related to the use of DNA repair targets for cancer therapy and serves on the consulting and scientific boards of several companies. Thus far Dr. Kelley’s research resulted in over 160 articles published in peer reviewed journals along with numerous reviews and book chapters.

1. Introduction and Overview of Current Targets: Bench to Clinic

Mark R. Kelley

2. MGMT a Critical DNA Repair Gene Target for Chemotherapy Resistance

Stanton L. Gerson and Lili Liu

3. Blockade of Base Excision Repair: Inhibitionof Small Lesions Results in Big Consequences to Cancer Cells

Melissa Fishel and Carlo Vascotto

4. PARP Inhibitors - Scientific Rationale and Clinical Development for Cancer

Ruth Plummer, Nicola J. Curtin and Yvette Drew

5. Inhibiting Selective DNA Polymerases for Therapeutic Intervention

Anthony J. Berdis

6. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications

John Turchi and Stephan M. Patrick

7. Homologous Recombination and ATM/ATR Targets

Henning Willers, Lee Zou and Heike N. Pfaffle

8. DNA Double Strand Break Repair by Nonhomologous End Joining and its Clinical Relevance

Michael Weinfeld and Susan Lees-Miller

9. Defective MMR-c-Abl-p73-GADD45alpha Expression in Cancer Chemoresistance

David Boothman and Long Shan Li

10. DNA Repair Signaling Targets

Susan Ashwell

11. Redox Regulation of DNA Repair and Therapeutic

Millie M. Georgiadis

12. Personalized Cancer Medicine: DNA Repair Alterations is a Promising Predictive Marker in Cancer

Srinivasan Madhusudan

13. The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies

Michael R. Vasko

14. Future Directions

Mark R. Kelley

Erscheinungsdatum	11.01.2017
Verlagsort	San Diego
Sprache	englisch
Maße	216 x 276 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-12-810360-4 / 0128103604
ISBN-13	978-0-12-810360-9 / 9780128103609
Zustand	Neuware