Animal Models for Human Cancer (eBook)

Marianne Martic is a senior assistant at the Transdisciplinary Laboratorium Collegium Helveticum, a joint institution of the Swiss Federal Institute of Technolgy (ETH) and the University of Zurich (UZH). She joined the institution after obtaining her degree at the radiopharmaceutical institute of ETH Zürich, where she has worked on animal experimental protocols in the field of positron emission tomography (PET). Her current research is focused on the systematic reviewing and meta-analysis of preclinical animal experiments. August Schubiger is a senior fellow at the Transdisciplinary Laboratorium Collegium Helveticum, a joint institution of ETH and UZH. He has been full Professor of Radiopharmacy at the Institute of Pharmaceutical Sciences at ETH Zurich and headed the Center for Radiopharmaceutical Science of the ETH, the Paul Scherrer Institute (PSI) and at the Clinic and Polyclinic for Nuclear Medicine at the UZH until 2010. He is currently involved in the project 'Drug development - significance and predictive value of animal testing'.

Preface

Introduction
Ethical Aspects of the Use of Animals in Translational Research
Study Design
Improving External Validity of Experimental Animal Data
How to End Selective Reporting in Animal Research
A Comprehensive Overview of Mouse Models in Oncology
Mouse Models of Advanced Spontaneous Metastasis for Experimental Therapeutics
Spontaneous Animal Tumor Models
Dog Models of Naturally Occurring Cancer
Improving Preclinical Cancer Models: Lessons from Human and Canine Clinical Trials of Metronomic Chemotherapy

Index