Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods

Dr. Christo Z. Christov teaches at Northumbria University, Ellison Building, Newcastle-upon-Tyne, UK

1. Molecular Modeling and Chemoinformatics to Advance the Development of Modulators of Epigenetic Targets: A Focus on DNA Methyltransferases Fernando D. Prieto-Martínez, Andrea Peña-Castillo, Oscar Méndez-Lucio, Eli Fernández-De Gortari and José L. Medina-Franco 2. Recent Advances in Computational Models for the Study Protein-Peptide Interactions Denise Kilburg and Emilio Gallicchio 3. Structural Plasticity in Globins: Role of Protein Dynamics in Defining Ligand Migration Pathways C. Estarellas, L. Capece, C. Seira, A. Bidon-Chanal, D. A. Estrin and F. J. Luque 4. Dynamic Reorganization and Enzymatic Remodeling of Type IV Collagen at Cell- Biomaterial Interface Nuno Miranda Coelho, Virginia Llopis-Hernández, Manuel Salmerón-Sánchez and George Altankov 5. Cytochromes P450: History, Classes, Catalytic Mechanism and Industrial Application Darren J. Cook, James D. Cook, Ken Cook, Gary W. Black and Simon J. Charnock 6. Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A Laura J. Kay, Tora K. Smulders-Srinivasan and Meera Soundararajan