Histamine Receptors -

Histamine Receptors

Preclinical and Clinical Aspects
Buch | Hardcover
XIV, 373 Seiten
2016 | 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-40306-9 (ISBN)
181,89 inkl. MwSt
A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.

Molecular aspects of histamine receptors.- Genetic polymorphisms in the histamine receptor family.- The role of the histamine H4 receptor in asthma and atopic dermatitis.- Identification and roles of zebrafish histamine receptors.- Histamine H3r antagonists: from scaffold hopping to clinical candidates.- Clinical significance of histamine H1 receptor gene expression and drug action of antihistamines.- Histamine and its receptors as a module of the biogenic amine diseasome.- Histaminergic regulation of blood-brain barrier activity.- Histamine function in nervous systems.- Heterogeneity of histaminergic neurons.- Modulation by histamine H3 receptors of neurotransmitter release in the basal ganglia.- Interaction of brain histaminergic and dopaminergic systems.- Histamine H1 Receptor Occupancy in Human Brain Measured by Positron Emission Tomography.- Modulation of memory consolidation and extinction by brain histamine.- Histamine and appetite.

Erscheinungsdatum
Reihe/Serie The Receptors
Zusatzinfo XIV, 373 p. 111 illus., 52 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Studium
Naturwissenschaften Biologie Humanbiologie
Schlagworte Biomedical and Life Sciences • Computational Analysis • learning and memory • neuroimaging • Neuropharmacology • Neurosciences • pharmacogenetics of the histamine system
ISBN-10 3-319-40306-0 / 3319403060
ISBN-13 978-3-319-40306-9 / 9783319403069
Zustand Neuware
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