Comet Assay in Toxicology

Professor Alok Dhawan (PhD, FNASc, ATS, FINS, FAEB, FSTOX) is currently the Director, Institute of Life Sciences, Ahmedabad University and Senior Principal Scientist, CSIR-Indian Institute of Toxicology Research, Lucknow. He obtained his PhD in Biochemistry from University of Lucknow, India in 1991. Professor Dhawan has won several honours and awards including INSA Young Scientists Medal in 1994, CSIR Young Scientist Award in 1999, the Shakuntala Amir Chand Prize of ICMR in 2001 and the Vigyan Ratna by the Council of Science and Technology, U.P. in 2011. He is the founder of the Indian Nanoscience Society established in 2007. He is the Member of various Government committees. He has to his credit several Fellowships of prestigious institutions in India and abroad such as The National Academy of Sciences, India; and The Academy of Toxicological Sciences, USA. Professor Diana Anderson (MSc, PhD, DipEd, FSB, FRCPath, FIFST, FATS, FBTS, FHEA, FRSM, FRSC) currently holds the Established Chair at the Department of Biomedical Sciences at the University of Bradford, UK. In 1974, Professor Anderson was appointed as Head of Mutagenesis Studies at ICI's Central Toxicology Laboratory and she joined BIBRA International in 1981 as Head of Genetic and Reproductive Toxicology and became Assistant Director and Group Forum Co-ordinator in 1987. In 1992, she became Senior Associate and Co-ordinator of External Affairs at BIBRA. She has contributed significantly in the fields of genetic & reproductive toxicology and molecular epidemiology.

The Comet Assay: A Versatile Tool for Assessing DNA Damage;

Detection of Oxidised DNA Using DNA Repair Enzymes;

Microplate-Based Comet Assay;

The Use of Higher Plants in the Comet Assay;

Methods for Freezing Blood Samples at −80 °C for DNA Damage Analysis in Human Leukocytes;

Development and Applications of the Comet-FISH Assay for the Study of DNA Damage and Repair;

Detection of DNA Damage in different organs of the Mouse;

Clinical Applications of the Comet Assay;

Applications of the Comet Assay in Human Biomonitoring;

The Comet Assay in Human Biomonitoring;

Comet Assays in Dietary Intervention Trials;

The Comet Assay for the Evaluation of Genotoxic Exposure in Aquatic Species;

The Alkaline Comet Assay in Prognostic Tests for Male Infertility and Assisted Reproductive Technology Outcomes;

he Comet Assay in Sperm – Assessing Genotoxins in Male Germ Cells;

Assessment of DNA Damage in alternate to animal models;

Neutral bacterial comet assay to assess DNA double-strand breaks in Escherichia coli;

In silico prediction of DNA Damage using the Comet Assay data;

Comet Assay – Protocols and Testing Strategies;

Imaging and Image Analysis in the Comet Assay;

Statistical Analysis of Comet Assay Data;

Meta-Analysis of the Comet Assay Data of Human Monitoring Studies;

Application of the Comet Assay in Nanotoxicology