C-Type Lectin Receptors in Immunity (eBook)
VI, 215 Seiten
Springer Tokyo (Verlag)
978-4-431-56015-9 (ISBN)
The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.
Sho Yamasaki, PhD, Professor at Kyushu University
The book presents the latest findingson C-type lectin receptors, focusing on individual receptors and theirsignaling. In recent years there have been great advances in the understandingof the function of these receptors as a newly emerging family of pattern-recognitionreceptors (PRRs) for pathogen-associated molecular patterns (PAMPs) anddamage-associated molecular patterns (DAMPs). Comprising four parts:ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearingReceptors; and Other Receptors and Related Topics, this comprehensive reviewcovers a broad range of C-type lectin receptors. The updated information onC-type lectin receptors and their ligands provided will appeal to a widereadership, from basic immunologists to physicians and surgeons. In addition,sections on novel drug development make this a valuable resource forpharmaceutical scientists.
Sho Yamasaki, PhD, Professor at Kyushu University
Part 1 ITAM-coupled Activating Receptors.- 1
Dectin-2 in anti-microbial immunity and homeostasis.- 2 The function of Mincle
as a danger sensor.- 3 The DAP12-Associated Myeloid C-type Lectin 5A (CLEC5A).-
Part 2 HemITAM-bearing Receptors.- 4 Dectin-1 (CLEC7A, BGR, CLECSF12).- 5 DNGR-1,
an F-actin-binding C-type lectin receptor involved in cross-presentation of
dead cell-associated antigens by dendritic cells.- 6 C-type lectin-like receptor
2 (CLEC-2).- Part 3 ITIM-bearing Receptors.- 7 Dendritic cell immunoreceptor
(DCIR): An ITIM-harboring C-type lectin receptor.- 8 Regulation and Function of
the Inhibitory C-type Lectin Clec12A/MICL.- Part 4 Other receptors and related
topics.- 9 DC-SIGN in infection and immunity.- 10 LOX-1 and immunity.- 11 MGL/CD301
as a unique C-type lectin expressed on dendritic cells and macrophages.- 12 Structural
aspects of C-type lectin receptors.- 13 The Ligands of C-Type Lectins.
| Erscheint lt. Verlag | 22.3.2016 |
|---|---|
| Zusatzinfo | VI, 215 p. 29 illus., 6 illus. in color. |
| Verlagsort | Tokyo |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Technik | |
| Schlagworte | Carbohydrate recognition domain • Danger-associated molecular patterns (DAMPs) • Immune receptor tyrosine-based activation motif (ITAM) • Immune receptor tyrosine-based inhibitory motif (ITIM) • Pathogen-associated molecular patterns (PAMPs) • signal transduction |
| ISBN-10 | 4-431-56015-7 / 4431560157 |
| ISBN-13 | 978-4-431-56015-9 / 9784431560159 |
| Haben Sie eine Frage zum Produkt? |
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