Kinase Drug Discovery (eBook)
332 Seiten
Royal Society of Chemistry (Verlag)
978-1-84973-355-7 (ISBN)
Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experience in the industry of well over 200 years, which has resulted in a book of great interest to the kinase field and across drug discovery more generally. Readers will gain a real insight into the huge challenges and opportunities which this target class has presented drug discovery scientists. The many chapters cover a wide breadth of topics, are well written and include high quality colour and black and white images. Topics covered include an outline of how medicinal chemistry has been able to specifically exploit this unique target class, along with reflections on the mechanisms of kinases inhibitors. Also covered is resistance to kinase inhibitors caused by amino acid mutations, case studies of kinase programs and reviews areas beyond protein kinases and beyond the human kinome. Also described are modern approaches to finding kinase leads and the book finishes with a reflection of how kinase drug discovery may progress over the coming years.
Richard A Ward and Frederick W Goldberg have both been working at AstraZeneca in Alderley Park for over 5 years. Richard Ward is a Computational Chemist and Frederick Goldberg is a Medicinal Chemist. They have worked on a significant number of kinase projects and are named on various kinase-related papers and patents and have both presented externally on the subject.
An Introduction to Kinase Inhibition;The Kinome and its Impact on Medicinal Chemistry; Modern Approaches to Hit Finding against Kinase Targets; The Evolution of Medicinal Chemistry against Kinase Targets; A Case Study of Kinase Inhibitors; Impact of Compound Selectivity on Kinase Inhibition; The Mechanism and Kinetics of Kinase Inhibitors; The Properties of Kinase Inhibitors; Balancing Efficacy and Safety of Kinase Inhibitors; Kinase Mutations and Resistance in Drug Discovery; Experiences with Targeting Kinases outside of Oncology; Non-Protein Kinases as Targets; The Challenges of Intellectual Property in Kinase Inhibition; The Future of Kinase Inhibition
Erscheint lt. Verlag | 14.12.2011 |
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Reihe/Serie | ISSN |
Verlagsort | Cambridge |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik) | |
Naturwissenschaften ► Biologie ► Biochemie | |
Naturwissenschaften ► Chemie | |
Schlagworte | Discovery • Drug • Kinase |
ISBN-10 | 1-84973-355-4 / 1849733554 |
ISBN-13 | 978-1-84973-355-7 / 9781849733557 |
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