Molybdenum and Tungsten Enzymes

This book is edited by Professor Russ Hille (University of California, Riverside), Professor Carola Schulzke (University of Greifswald) and Professor Martin Kirk (University of New Mexico) who have over 275 publications ad over 65 years of experience between them in the field. Their complementary expertise in molybdenum containing enzymes, bioinorganic chemistry and the physical inorganic chemistry of molybdenum complexes and enzymes, respectively, allow the authoritative and comprehensive coverage demonstrated in this book.

Part I Molybdenum- and tungsten-containing enzymes;

Abundance, ubiquity, and evolution of molybdoenzymes;

Molybdenum cofactor biosynthesis;

Bacterial molybdoenzymes;

The prokaryotic Mo/W-bisPGD enzyme family;

Enzymes of the xanthine oxidase family;

The sulfite oxidase family of Mo enzymes;

Nitrogenase;

Tungsten-containing enzymes;

Part II Introduction and overview of synthetic Mo and W chemistry;

Synthesis of mono- and bisdithiolene Mo and W model compounds;

Pterin‐inspired Model Compounds of Molybdenum Enzymes;

Synthesis of models for the xanthine oxidase family of enzymes;

Electron transfer mechanisms in Mo and W compounds;

Comparative kinetics of enzymes and models;

Models of the metal clusters of nitrogenase;

Part III Overview of spectroscopic and electronic studies of Mo and W enzymes;

Spectroscopic and electronic structure studies of Mo model compounds and enzymes;

Electron paramagnetic resonance studies of molybdenum enzymes;

X-ray absorption spectroscopic studies of molybdenum enzymes;

Electrochemistry of molybdenum and tungsten enzymes;

Computational studies of molybdenum and tungsten enzymes;

Nitrogen Fixation in Nitrogenase and Related Small-Molecule Models