Chromosome 12 Aberrations in Human Solid Tumors

A comprehensive overview of the types of aberrations that chromosome 12 present in human solid tumours. The authors explore the implications for a cytogenetic subtyping of the tumours involved, along with strategies for identifying the molecular changes that underlie karyotypic alterations.

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Researchers involved in the cytogenetics and molecular genetics of human tumors will welcome this comprehensive overview of the type of aberrations that chromosome 12 presents in human solid tumors. The authors study the implications for a cytogenetic subtyping of the tumors involved and strategies for identifying the molecular changes which underlie the karyotypic alterations. The aberrations of chromosome 12 which the book deals with are the most frequent chromosomal alterations in human tumors occuring in frequent benign tumors, such as uterine leiomyomas and lipomas, and in malignant tumors of mesenchymal and epithel origin, such as pleomorphic adenomas of the salivary glands.