This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.
- Updated information regarding the most recent in vitro models to study the permeability of drugs
- Short and concise chapters covering all the biological barriers with interest in drug permeability
- A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models
- Simple and clear scientific content, adaptable for young scientists and experimented researchers
Bruno Sarmento is an Affiliated Investigator at the INEB-Instituto de Engenharia Biomédica, based at the University of Porto, Portugal and is Assistant Professor of Pharmaceutical Technology in the Department of Pharmaceutical Sciences, at ISCS-N, Gandra, Portugal. His current research is focused on the study of nanomedicines and their application in the pharmaceutical and biomedical fields, as well as the use of in vitro cell models as a tool to correlate the transport of biopharmaceuticals and nanoparticles across human mucosa. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. He also serves as an editorial board member for several international journals and an evaluator of research projects form international agencies. He is an active member of several international associations (AAPS, CRS, EUFEPS, EFSD, FIP) and works on biotechnology and health post-graduate programs at national and international level.
This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. Updated information regarding the most recent in vitro models to study the permeability of drugs Short and concise chapters covering all the biological barriers with interest in drug permeability A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models Simple and clear scientific content, adaptable for young scientists and experimented researchers
List of contributors
João Albuquerque, University of Porto, Porto, Portugal
Isabel Almeida, University of Porto, Porto, Portugal
Fernanda Andrade
Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Porto, Portugal
Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain
Francisca Araújo
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
Marival Bermejo Sanz, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España
Malgorzata Burek, Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
Miguel Ángel Cabrera Pérez
Universidad Central Marta Abreu de Las Villas, Santa Clara, Villa Clara, Cuba
Universidad Miguel Hernández, San Juan de Alicante, Alicante, España
Pedro Castro, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal
Luise Chaves, UCIBIO/REQUIMTE—Laboratory of Applied Chemistry, University of Porto, Porto, Portugal
João Coentro
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal
Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
Ana Costa
Instituto de Engenharia Biomédica (INEB), University of Porto, Porto, Portugal
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal
Joana Costa
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
FEUP—Faculdade de Engenharia da Universidade do Porto, Porto, Portugal
Paulo Costa, University of Porto, Porto, Portugal
Sara Baptista da Silva
Faculty of Pharmacy, University of Porto, Porto, Portugal
CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal
José das Neves
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
Tiago dos Santos, INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Domingos Ferreira, Faculty of Pharmacy, University of Porto, Porto, Portugal
Carola Y. Förster, Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
Isabel González Álvarez, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España
Marta González-Álvarez, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España
Luís Gouveia, iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
Pedro L. Granja
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal
Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
Jouni Hirvonen, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Maria João Gomes
INEB—Instituto de Engenharia Biomédica, Universisdade do Porto, Porto, Portugal
ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saude, Universidade do Porto, Porto, Portugal
Christian Kölln, Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany
Bianca N. Lourenço
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Faculdade de Engenharia da Universidade do Porto (FEUP), Porto, Portugal
Alexandra Machado
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
Raquel Madureira, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal
Victor Mangas Sanjuan, Universidad Miguel Hernández, San Juan de Alicante, Alicante, España
Sara Marques, CIBIO/InBIO-UP—Centro de Investigação em Biodiversidade e Recursos Genéticos, University of Porto, Campus Agrário, Vairão, Portugal
Susana Martins, University of Southern Denmark, Odense, Denmark
Bárbara Mendes
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saude, Universidade do Porto, Porto, Portugal
José Augusto Guimarães Morais, iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
Rute Nunes, INEB—Instituto de Engenharia Biomédica, University of Porto, Porto, Portugal
Maria Beatriz P.P. Oliveira, Requimte, Faculty of Pharmacy, University of Porto, Porto, Portugal
Paulo Paixão, iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
Carla Pereira
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
FEUP—Faculdade de Engenharia da Universidade do Porto, Porto, Portugal
Manuela Pintado, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal
Stephan Reichl, Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany
Francisca Rodrigues
Requimte, Faculty of Pharmacy, University of Porto, Porto, Portugal
Fourmag Lda, Parque Industrial do Cruzeiro, Moreira de Cónegos, Portugal
Ellaine Salvador, Department of Anaesthesia and Critical Care, University of Wurzburg, Wurzburg, Germany
Hélder A. Santos, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Bruno Sarmento
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
INEB—Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, Departamento de Ciências Farmacêuticas, Gandra-PRD, Portugal
Neha Shrestha, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Cátia Silva, CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra PRD, Portugal
Nuno Silva, iMed.UL, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
Nataša Škalko-Basnet, University of Tromsø The Arctic University of Norway, Tromsø, Norway
Alejandro Sosnik, Technion-Israel Institute of Technology, Technion City, Haifa, Israel
Flávia Sousa, CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, Gandra PRD, Portugal
Ingunn Tho, University of Oslo, Oslo, Norway
Ana Vanessa Nascimento
University of Porto, Porto, Portugal
IINFACTS, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, CESPU, Cooperativa...
| Erscheint lt. Verlag | 1.10.2015 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| ISBN-10 | 0-08-100114-2 / 0081001142 |
| ISBN-13 | 978-0-08-100114-1 / 9780081001141 |
| Haben Sie eine Frage zum Produkt? |
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