Basement Membranes

Dr.Jeffrey H. Miner, PhD, received his doctorate in Molecular Biology and Biochemistry in 1991 from the California Institute of Technology in Pasadena, CA. In 1992 he moved to Washington University in St. Louis for postdoctoral training with Dr. Joshua R. Sanes. In 1996 he was appointed Assistant Professor of Medicine in the Washington University School of Medicine Renal Division, where he has maintained a lab ever since and is currently a tenured Professor. During his postdoctoral fellowship Dr. Miner developed an interest in the roles of collagen IV and laminin in basement membrane function, particularly regarding the glomerular basement membrane of the kidney. He was the first to demonstrate developmental transitions in basement membrane protein isoforms in the developing kidney, and went on to show in knockout mouse models that these transitions are crucial for normal kidney development and function. He discovered the laminin Α5 chain, a widely expressed laminin chain important in several crucial developmental processes, as well as in kidney function. He has continued to focus on rare diseases of the glomerular basement membrane caused by mutations in collagen IV (Alport syndrome) and laminin Β2 (Pierson syndrome and a related congenital nephrotic syndrome) using the mouse as a model. This work has implicated the glomerular basement membrane as a critical component of the kidney’s ultrafiltration barrier that impedes the passage of plasma proteins into the urine. In 2004 he received the American Society of Nephrology’s Young Investigator Award. In 2008 he was Chair of the Gordon Research Conference on Basement Membranes. He was a Councilor of the American Society for Matrix Biology from 2009-2012. Dr. Miner has received grant funding from the National Science Foundation (predoctoral fellowship), the Damon Runyon Cancer Research Fund (postdoctoral fellowship), the National Institutes of Health, the March of Dimes, the American Heart Association (Establish Investigator Award and Grant-in-Aid), and the Alport Syndrome Foundation. He has also received research support from industry, including Creative Biomolecules, Biogen, Hoffmann-La Roche, and Third Rock Ventures.

Integrating Activities of Laminins that Drive Basement Membrane Assembly and Function
Peter D. Yurchenco
Laminin-a2 Chain-Deficient Congenital Muscular Dystrophy: Pathophysiology and Development of Treatment
Madeleine Durbeej
Type IV Collagens and Basement Membrane Diseases: Cell Biology and Pathogenic Mechanisms
Mao Mao, Marcel V. Alavi, Cassandre Labelle-Dumais and Douglas B. Gould
Epidermal Basement Membrane in Health and Disease
Cristina Has and Alexander Nyström
Applying Proteomics to Investigate Extracellular Matrix in Health and Disease
Michael Randles and Rachel Lennon
Molecular Basis of Laminin–Integrin Interactions
Masashi Yamada and Kiyotoshi Sekiguchi
Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View
Corina M. Borza, Xiwu Chen, Roy Zent and Ambra Pozzi
The Basement Membrane Proteoglycans Perlecan and Agrin:  Something Old… Something New
Kevin J. McCarthy
Building From the Ground Up: Basement Membranes in Drosophila Development
Adam J. Isabella and Sally Horne-Badovinac
Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues
Matthew R. Clay and David R. Sherwood