Targeting the Broadly Pathogenic Kynurenine Pathway (eBook)

Part I. Overview.- Overview of the Kynurenine Pathway of Tryptophan Metabolism.- Role of Tryptophan Metabolism in Health and Disease.- Nutritional Aspects of Tryptophan Metabolism.- Role of Kynurenine Pathway in Early Brain Development.- Role of Kynurenine Pathway in Aging.- Role of Tryptophan Metabolism in Mood, Behavior, and Cognition.- Part II. Systemic Diseases.- Role of Kynurenine Pathway in Inflammatory Diseases.- Role of Kynurenine Pathway in Allergy.- Role of Kynurenine Pathway in HIV/AIDS.- Role of Kynurenine Pathway in Cardiovascular Disease.- Role of Kynurenine Pathway in Respiratory Diseases.- Role of Kynurenine Pathway in Gastrointestinal Diseases.- Role of Kynurenine Pathway in Insulin Resistance.- Role of Kynurenine Pathway in Infections.- Part III. CNS Disorders.- Role of Kynurenine Pathway in Neurodegenerative Diseases.- Role of Kynurenine Pathway in Epilepsy.- Role of Kynurenine Pathway in Stroke.- Role of Kynurenine Pathway in Pain and Migraines.- Role of Kynurenine Pathway in Autism Spectrum Disorders.- Role of Kynurenine Pathway in Neuropsychiatric Disorders.- Part IV. Oncology.- Role of Kynurenine Pathway in Stem Cell Biology.- Role of Kynurenine Pathway in Cancer Biology.- Role of Kynurenine Pathway in Neuro-oncology.- Role of the Kynurenine Pathway in Hematologic Malignancies.- Part V. Experimental Models and in Vivo Imaging.- Experimental Models to Study the Kynurenine Pathway.- Animal Models to Study the Role of Kynurenine Pathway in Mood, Behavior, and Cognition.- Applications of Small Animal PET Imaging.- Molecular Imaging of Serotonin Synthesis in the Brain.- Molecular Imaging of Tryptophan Metabolism.- Part VI. Therapeutic Approaches.- Inhibition of the Kynurenine Pathway of Tryptophan Catabolism.- Clinical Trials Targeting the Kynurenine Pathway.- The Next Decade in Tryptophan Metabolism Research.