Principles of Virology

Jane Flint is a Professor of Molecular Biology at Princeton University. Dr. Flint's research focuses on investigation of the molecular mechanisms by which gene products of adenoviruses modulate host cell pathways and anti-viral defenses to allow efficient reproduction in normal human cells. Vincent Racaniello is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. Dr. Racaniello has been studying viruses for over 35 years, including poliovirus, rhinovirus, enteroviruses, and hepatitis C virus. Dr. Racaniello blogs about viruses at virology.ws and is host of the popular science program This Week in Virology.

Volume I Molecular Biology


Part I The Science of Virology


1 Foundations


2 The Infectious Cycle


Part II Molecular Biology


3 Genomes and Genetics


4 Structure


5 Attachment and Entry


6 Synthesis of RNA from RNA Templates


7 Reverse Transcription and Integration


8 Synthesis of RNA from DNA Templates


9 Replication of DNA Genomes


10 Processing of Viral Pre-mRNA


11 Protein Synthesis


12 Intracellular Trafficking


13 Assembly, Exit, and Maturation


14 The Infected Cell


Appendix Structure, genome organization, and infectious cycles


Glossary


Index


Volume II Pathogenesis and Control


1 Infections of Populations: History and Epidemiology


2 Barriers to Infection


3 The Early Host Response: Cell-Autonomous and Innate Immunity


4 Adaptive Immunity and the Establishment of Memory


5 Mechanisms of Pathogenesis


6 Cellular Transformation and Oncogenesis


7 Human Immunodeficiency Virus Pathogenesis


8 Vaccines


9 Antiviral Drugs


10 Evolution


11 Emergence


12 Unusual Infectious Agents


Appendix Diseases, Epidemiology, and Disease Mechanisms of Selected Animal Viruses Discussed in This Book


Glossary


Index