Inflammatory Pathways in Diabetes

Dr. Pugia is the Principal Key Expert at Siemens Healthcare Diagnostics in the Strategic Innovation Group in Strategy and Business Development. Over the last 25 years, he has held various Research & Development positions and been involved in over 20 new products in the MULTISTIX, CLINITEK, CLINITEST and DCA brands for urinalysis and professional diabetes as well as other business units. He has a Ph.D. in Chemistry from Texas Tech University (1986), a B.S. in Chemistry from Clarkson University (1982) and was Visiting Scholar at the University of Notre Dame (2004-2008). His research areas are proteomic biomarker discovery and treatment in inflammatory immune diseases in the field of endocrinology and onocology. He has 256 patents world wide, 48 full-length manuscripts and 6 book chapters in a wide variety of chemistry disciplines. In 2009, he was a Siemens Inventor of the Year, he was the first Al Free Memorial Lecturer in 2001 and in 2002 was awarded the Samual Natelson Award by the American Association for Clinical Chemistry. He has also been awarded nine corporate Science and Technology Awards while in Bayer and Miles Diagnostics.

Part 1. Introduction.- 1. Impact of inflammation and the innate immunity response in obesity mediated diabetes (lit review).- Part 2. Impact of complement on diabetic disease.- 2. Complement and Complement Regulatory Proteins in Diabetes.- Part 3. Role of C terminal fragment of adiponectin receptor in inhibition of insulin degradation.- 3. Development of adiponectin receptor C terminal fragment bioassays.- 4. Protease inhibition and biological distribution of the C terminal fragment of adiponectin receptor.- 5. Cell & biological models for the C terminal fragment of adiponectin receptor.- 6. C-Terminal fragment of adiponectin receptor clinical correlations.- Part 4. Uristatin assay for prediction of renal and other clinical events.- 7. Uristatin immunoassay usage in glomerular nephritis assessment.- 8. Acute Response of Uristatin in Surgery.- 9. Cardiovascular and metabolic syndrome impact on uristatin.- 10. Uristatin anti-inflammatory cellular signaling.- Part 5. Summary.- 11. Overview of progress in new markers for diabetes inflammation (Literatue Review).