Fundamentals of Biochemistry

Donald Voet received a Ph.D. in chemistry from Harvard University and did postdoctoral research in the Biology Department at MIT. Don took up a faculty position in the department of chemistry at the University of Pennsylvania, upon completing his postdoctoral work. He has been a visiting scholar at Oxford University, the University of California San Diego, and the Weismann Institute of Science in Israel. Judith Voet received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education.

Part I Introduction

1 Introduction to the Chemistry of Life 1

2 Water 23

Part II Biomolecules

3 Nucleotides, Nucleic Acids, and Genetic Information 42

4 Amino Acids 80

5 Proteins: Primary Structure 97

6 Proteins: Three-Dimensional Structure 131

7 Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies 180

8 Carbohydrates 221

9 Lipids and Biological Membranes 245

10 Membrane Transport 293

Part III Enzymes

11 Enzymatic Catalysis 322

12 Enzyme Kinetics, Inhibition, and Control 361

13 Biochemical Signaling 402

Part IV Metabolism

14 Introduction to Metabolism 442

15 Glucose Catabolism 478

16 Glycogen Metabolism and Gluconeogenesis 523

17 Citric Acid Cycle 558

18 Electron Transport and Oxidative Phosphorylation 588

19 Photosynthesis

20 Lipid Metabolism 664

21 Amino Lipid Metabolism 718

22 Mammalian Fuel Metabolism: Integration and Regulation 773

Part V Gene Expression and Replication

23 Nucleotide Metabolism 802

24 Nucleic Acid Structure 831

25 DNA Replication, Repair, and Recombination 879

26 Transcription and RNA Processing 938

27 Protein Synthesis 982

28 Regulation of Gene Expression 1033

Glossary I- 1

Index I- 1