Sleep, Neuronal Plasticity and Brain Function

Preface.- Basics of sleep and wakefulness. Genetic dissection of sleep homeostasis.- Sleep, sleep deprivation and gene expression.- Sleep and synaptic homeostasis.- Sleep and neuronal plasticity.- Sleep and adult neurogenesis: implications for cognition and mood.- Sleep & memory: molecular mechanisms.- Sleep & memory in birds.- MRI studies of sleep and memory in humans.- Sleep & memory: cognitive function in humans.- Sleep and cognition in ageing and dementia.- The adenosine system, caffeine, and performance.- Orexin/Hypocretin regulation of arousal and optogenetics.- Sleep, stress and arousal.- Sleep and emotional regulation.- Sleep and psychiatric disorders (PTSD, anxiety, aggression, schizophrenia).- Sleep disruption as a causal factor in depression.- Sleep deprivation therapy for depression.- Pharmacology of sleep and sleep disorders.

"This is an extensive overview of the relationship between sleep, neuronal plasticity, and brain function. It reviews the developments and progress being made in the attempt to understand the function of sleep. ... The audience will be individuals interested in the neurophysiology of the brain and changes related to sleep states. Students, researchers, and clinicians with an interest in the neurobiological aspects of sleep, sleep deprivation, and its effect on cognitive functioning will find the book useful." (Michael Easton, Doody's Book Reviews, November, 2015)