TRP Channels as Therapeutic Targets

Arpad Szallasi is a leading expert on the roles of TRP channels in health and disease. He was the first to provide a biochemical proof for the existence of the vanilloid (capsaicin) receptor, now known as TRPV1. Currently, he holds an Associate Professor position at the 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. His research focuses on targeting of TRP channels for therapeutic purposes, with special emphasis on pain and inflammation. Arpad Szallasi obtained his MD degree Summa cum Laude from the Medical University School of Debrecen, Hungary (1984). He received his PhD degree in Pharmacology from the Karolinska Institute, Stockholm, Sweden (1995). Arpad Szallasi held several research positions both in academia (Karolinska Institute, Washington University, St. Louis, MO) and industry (Menarini Ricerche Sud, Pomezia, Italy) before pursuing a carrier in diagnostic pathology. Arpad Szallasi is a past President for the New Jersey Association of Blood Bank Professional and a former medical advisor to the American Red Cross.

1. Introduction
2. Hereditary TRP Channelopathies
3. Changes in TRP Channel Expression in Acquired Diseases
4. TRP Gene Polymorphism and Disease Risk
5. Topical Capsaicin for Pain Relief
6. TRPV1 agonist cytotoxicity for chronic pain relief
7. Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders
8. Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents
9. TRPA1 Antagonists for Pain Relief
10. TRPA Antagonistsas Therapeutic Strategies to Reduce the Symptoms and Pathophysiology of Respiratory Disorders
11. TRPV3 Receptors as Drug Targets: A Decade of Learning
12. Small Molecule Agonists and Antagonists of TRPV4
13. Potential Therapeutic Applications for TRPV4 Antagonists in Lung Disease
14. TRPM8 as a Target for Analgesia
15. TRP Channels: Connectivity to Cerebral Vascular Disease
16. TRP Channels' Key Role in the Transduction of Itch
17. Role of TRP Channels in Skin Diseases
18. TRP Channels in Obesity/Metabolic Syndrome
19. TRP Channels in Diabetes
20. TRP Channels and Ca²+ Entry in Cardiac Disease
21. The Contribution of TRP Channels to Pathophysiological Regulation of the Gastrointestinal Tract
22. Cancer: Oncogenic and Anti-Oncogenic TRP Channels as Biomarkers and Therapeutic Targets
23. TRP Channels in the Brain
24. A: Mucolipidosis and TRPML Channels
24 B: TRPML1-dependent Processes as the Therapeutic Targets
25. TRPs in respiratory disorders: opportunities beyond TRPA1
26. Concluding Remarks