Hydrogen Sulfide in Redox Biology Part A

ENRIQUE CADENAS, MD, PhD, received his PhD in biochemistry from the University of Buenos Aires, School of Medicine. He is professor of pharmacology and pharmaceutical sciences at the University of Southern California School of Pharmacy and of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, and doctor honoris causa (medicine) at the University of Linköping, Sweden. Cadenas was president of the Society for Free Radical Research International (SFRRI) and is fellow of the Society for Free Radical Biology & Medicine. He served the scientific community by participating on NIH study sections (2002-2006; chair 2006-2008). His research interests include energy and redox metabolism in brain aging and the coordinated inflammatory-metabolic responses in brain and neurodegenerative diseases. Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California. Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l’Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California. He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology: Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the “Antioxidant Network” regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell’s redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

HYDROGEN SULFIDE DETECTION METHODS
1. Mechanistic Chemical Perspective of Hydrogen Sulfide Signaling
Péter Nagy
2. Measurement of H2S in vivo and in vitro by the Monobromobimane Method
Xinggui Shen, Gopi K. Kolluru, Shuai Yuan and Christopher Kevil
3. Hydrogen Sulfide Detection Using Nucleophilic Substitution-Cyclization Based Fluorescent Probes
Bo Peng, Ming Xian
4. Azide-Based Fluorescent Probes: Imaging Hydrogen Sulfide in Living Systems
Vivian S. Lin, Alexander R. Lippert and Christopher J. Chang
5. Chemiluminescent Detection of Enzymatically Produced H2S
T. Spencer Bailey and Michael D. Pluth
6. Quantification of Hydrogen Sulfide Concentration Using Methylene Blue and 5,5’-dithiobis(2-nitrobenzoic acid) Methods in Plants
Zhong-Guang Li
7. H2S Analysis in Biological Samples Using Gas Chromatography with Sulfur Chemiluminescence Detection
Victor Vitvitsky and Ruma Banerjee
HYDROGEN SULFIDE DONORS AND THEIR PHARMACOLOGICAL ACTIVITY
8. Use of Phosphorodithioate-Based Compounds as Hydrogen Sulfide Donors
Chung-Min Park and Ming Xian
9. GYY4137, a Novel Water-soluble, H2S-releasing Molecule
Peter Rose, Brian W. Dymock and Philip K. Moore
10. Neuroprotective Effects of Hydrogen Sulfide in Parkinson’s Disease Animal Models: Methods and Protocols
Xue Xue and Jin-Song Bian
HYDROGEN SULFIDE METABOLISM IN MAMMALIAN TISSUES
11. Assay Methods for H2S Biogenesis and Catabolism Enzymes
Ruma Banerjee, Taurai Chiku, Omer Kabil, Marouane Libiad, Nicole Motl and Pramod K. Yadav
12. Oxidation of H2S in Mammalian Cells and Mitochondria
Abbas Abou-Hamdan, Hala Guedouari-Bounihi, Véronique Lenoir, Mireille Andriamihaja,  François Blachier and Frédéric Bouillaud
13. Redox Regulation of Mammalian 3-mercaptopyruvate Sulfurtransferase
Noriyuki Nagahara, Masatoshi Nagano, Takaaki Ito and Hidenori Suzuki
14. Role of Human Sulfide:quinone Oxidoreductase in H2S Metabolism
Michael R. Jackson, Scott L. Melideo and Marilyn Schuman Jorns
15. H2S Regulation of Nitric Oxide Metabolism
Gopi K. Kolluru, Shuai Yuan, Xinggui Shen and Christopher G. Kevil