Hydrogen Sulfide in Redox Biology Part B

ENRIQUE CADENAS, MD, PhD, received his PhD in biochemistry from the University of Buenos Aires, School of Medicine. He is professor of pharmacology and pharmaceutical sciences at the University of Southern California School of Pharmacy and of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, and doctor honoris causa (medicine) at the University of Linköping, Sweden. Cadenas was president of the Society for Free Radical Research International (SFRRI) and is fellow of the Society for Free Radical Biology & Medicine. He served the scientific community by participating on NIH study sections (2002-2006; chair 2006-2008). His research interests include energy and redox metabolism in brain aging and the coordinated inflammatory-metabolic responses in brain and neurodegenerative diseases. Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California. Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l’Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California. He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology: Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the “Antioxidant Network” regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell’s redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

THE REDOX BIOCHEMISTRY OF HYDROGEN SULFIDE 1. Investigating the Role of H2S in 4-HNE Scavenging Hilde Laggner and Bernhard M.K. Gmeiner 2. Inhalation Exposure Model of Hydrogen Sulfide (H2S)-Induced Hypometabolism in the Male Sprague-Dawley Rats Asaf Stein, David W. Kraus, Jeannette E. Doeller and Shannon M. Bailey

MECHANISMS OF H2S CELL SIGNALING AND TRANSCRIPTIONAL PATHWAYS 3. Use of the “Tag-Switch” Method for the Detection of Protein S-Sulfhydration Chung-Min Park, Igor Macinkovic, Milos R. Filipovic, Ming Xian 4. Real-Time Assays for Monitoring the Influence of Sulfide and Sulfane Sulfur Species on Protein Thiol Redox States Romy Greiner and Tobias P. Dick 5. Sulfhydration of H2S Protein Targets Bindu D. Paul and Solomon H. Snyder

H2S IN CELL SIGNALING IN THE CARDIOVASCULAR AND NERVOUS SYSTEM AND INFLAMMATORY PROCESSES 6. Intravital Microscopic Methods to Evaluate Anti-inflammatory Effects and Signaling Mechanisms Evoked by Hydrogen Sulfide Mozow Y. Zuidema and Ronald J. Korthuis 7. Attenuation of Inflammatory Responses by Hydrogen Sulfide (H2S) in Ischemia / Reperfusion Injury Neel R. Sodha and Frank W. Sellke 8. CD47-dependent Regulation of H2S Biosynthesis and Signaling in T Cells Sukhbir Kaur, Anthony L. Schwartz, Thomas W. Miller and David D. Roberts 9. Anti-Inflammatory and Cytoprotective Properties of Hydrogen Sulfide Burcu Gemici and & John L. Wallace 10. H2S and Substance P in Inflammation Madhav Bhatia 11. Role of Hydrogen Sulfide (H2S) in Brain Synaptic Remodeling Pradip Kumar Kamat, Anuradha Kalani and Neetu Tyagi

H2S IN PLANTS 12. Detection of Thiol Modifications by Hydrogen Sulfide Williams, E., Pead, S., Whiteman, M., Wood, M.E., Wilson, I.D., Ladomery, M.R., Teklic, T., Lisjak, M. and Hancock, J.T. 13. Analysis of Some Enzymes Activities of Hydrogen Sulfide Metablism in Plants Zhong-Guang Li 14. Sulfide Detoxification in Plant Mitochondria Hannah Birke, Tatjana M. Hildebrandt, Markus Wirtz and Rüdiger Hell

MOLECULAR HYDROGEN 15. Molecular Hydrogen as a Novel Antioxidant: Overview of the Advantages of Hydrogen for Medical Applications Shigeo Ohta