Steroidal Activity in Experimental Animals and Man (eBook)

Front Cover 1
Steroidal Activity in Experimental Animals and Man, Part B 4
Copyright Page 5
Table of Cotents 10
CONTRIBUTORS TO VOLUME IV 6
PREFACE 8
CONTENTS OF PREVIOUS VOLUMES 12
Chapter 1. Thermogenic Properties of Steroids 14
I. Introduction 14
II. Thermogenic Action of Progesterone 15
III. Steroid Pyrogens: C19 Series 17
IV. Steroid Pyrogens: C21 Series 19
V. Steroid Pyrogens : C24 Series 20
VI. Steroid Pyrogen Conjugates 21
VII. Species Specificity of Steroid Pyrogen Action 22
VIII. Characteristics of Steroid Pyrogen Action in Man 23
IX. Metabolism of Steroid Pyrogens 27
X. Mechanisms of Steroid Fever 28
X I. Clinical Significance of Thermogenic 
29 
References 30
Chapter 2. Anabolic Steroids 34
I. Introduction 34
II. Relative Activity in the Animal 35
III. Relative Activity in Man 77
References 84
Chapter 3. Anti-Androgens 90
Text 90
References 106
Chapter 4. Anti-Progestational Compounds 108
Text 108
References 117
Chapter 5. Steroids in Reactivated Prostatic Cancer 118
I. Treatment of Relapse 119
II. Experimental Prostatic Cancer 
121 
III. The Cooperative Study Program 123
IV. The Nature of Relapse 127
V. Summary and Conclusions 132
References 133
Chapter 6. Steroids and Tumorigenesis in Experimental Animals 136
I. General Considerations 
136 
II. Mammary Tumors 141
III. Testicular Interstitial Cell Tumors 
153 
IV. Pituitary Tumors 161
V. Neoplasms of the Female Genital Tract 164
VI. Renal Tumors in the Hamster 166
VII. Lymphoid Tumors in Mice 167
VIII. Miscellaneous Considerations 170
References 173
Chapter 7. Inhibition of Tumor Growth by Steroids 178
Text 178
References 202
Chapter 8. Effects of Steroids on the Pancreas 206
I. Introductory Information Concerning the Pancreas 206
II. Steroids and the Endocrine Pancreas 208
III. Effects of Steroids on the Exocrine 
232 
IV. Summary 240
References 241
Chapter 9. Effects of Corticoide and ACTH on the Induction of Gastric Ulcers in Laboratory Animals 248
I. Methodology 249
II. The Normal Stomach as Influenced by Corticoids and ACTH 261
III. Influence of Corticoids and ACTH on the Development of Artificial Gastric Ulcers 268
IV. Healing of Gastric Ulcers as Influenced by Corticoids and ACTH 277
V. Relation between Gastric and Other Effects of Corticoids 278
VI. Experimental Data and Clinical Features 280
References 282
Chapter 10. The Influence of Steroids on ß- 
286 
I. Introduction 286
II. Renal ß-Glucuronidase Response 289
III. Studies on Biological Mechanisms 325
References 338
AUTHOR INDEX 340
SUBJECT INDEX 358