Bone and Mineral Research Annual

This volume reviews the prevalence, pathophysiology and consequences of primary hyperparathryroidism, one of the most common endocrine disorders. It covers the role of vitamin D in disorders of proliferation and contains contributions on: bone remodelling, Sillience, and the bisphosphonates.

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Although the regulation and mechanism of action of the major calcium regulating hormones (such as vitamin D and parathyroid hormone) have long been recognised, there are more important gaps in knowledge. This volume reviews the prevalence, patholophysiology and consequences of primary hyperparathyroidism, one of the most common endocrine disorders. It covers the potential role of vitamin D in disorders of proliferation, providing some thoughtful insights into the signals for parathyroid gland profileration and secretation, and making the important distinction between the two. The volume also contains contributions in the areas of: bone remodelling (including the cytokines and their regulation in physiology of bone call function, of bone disease; aspects of regulation of cartilage differentation and metabolism; and TGFB, one of the major non-collagenous cytokines in bone); the broad clinical classification of Sillience; and the bisphosphonates (including their use in Paget's disease, tumor induced bone disease, hyperpathyroidism and osteoporosis; and their structure, function, pharmacokinetic mechanism of action and the therapeutic implications.