Abeta Peptide and Alzheimer's Disease

A Brief Introduction to the History of the ?-Amyloid Protein (A?) of Alzheimer’s Disease.- The A?centric Pathway of Alzheimer’s Disease.- The Function of the Amyloid Precursor Protein Family.- The Involvement of A? in the Neuroinflammatory Response.- Amyloid ?-Peptide(1-42), Oxidative Stress, and Alzheimer’s Disease.- Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer’s Disease.- A? Variants and Their Impact on Amyloid Formation and Alzheimer’s Disease Progression.- Copper Coordination by ?-Amyloid and the Neuropathology of Alzheimer’s Disease.- Cholesterol and Alzheimer’s Disease.- Amyloid ?-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer’s Disease Pathology.- Physiologic and Neurotoxic Properties of A? Peptides.- Impact of ?-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models.- Glial Cells and A? Peptides in Alzheimer’s Disease Pathogenesis.- The Role of Presenilins in A?-Induced Cell Death in Alzheimer’s Disease.- Immunotherapeutic Approaches to Alzheimer’s Disease.- Mouse Models of Alzheimer’s Disease.