The Biological Role of Proteinases and Their Inhibitors in Skin

Preface. List of contributors. Lysosomal thiol proteinases and their endogenous inhibitors in rat skin. Physiological inhibitors of the human lysosomal cysteine proteinases. Localization of cathepsins H and L and their inhibitors in stratified epithelia and lymphatic tissue. Structure and function of epidermal proteases and their inhibitors. Recent advances in studies on tissue-type plasminogen activator. Proteases, angiogenesis, and invasion. Plasminogen activator of human epidermis: characterization of the enzymes and modulation by anti-cell surface antibodies. Characterization of high-molecular-weight plasminogen activator produced by cultured human epidermal cells. Calpain and calpastatin: biochemical and immunohistochemical distribution studies in various tissues. Biochemical and immunohistochemical studies of calpain in human skin. Calcium-activated neutral protease is a chimeric protein with distinct functional domains. The role of leukocyte cathepsin G and chymase in inflammation. Human skin tryptase. Murine leprosy: an animal model to investigate the proteinase-proteinase inhibitor regulation system in inflammation. Keratin-hydrolyzing enzyme in psoriatic epidermis. The biological role of keratinolytic proteinase and its inhibitor on the growth of Candida albicans. The physiological role of plasma proteinase inhibitors. Low-molecular-weight protease inhibitors produced by microorganisms. Isolation and characterization of a low-molecular-weight (2,200 Mr.) proteinase inhibitor of human epidermis. The biologial role of proteinases and their inhibitors in the pathogenesis of epidermolysis bullosa-recessive dystrophic and simplex types. Reverse regulation of *g-glutamyl transpeptidase (*g-GTP) in cultured melanotic B-16 melanoma cells by L-glutamine. A humoral factor affecting basophils in contact sensitivity. Index.