Issues in Clinical Epileptology: A View from the Bench (eBook)

PrefaceForeword Jerome Engel, Marc A. Dichter Part I  Seizures, epileptiform activities and regional localization 1 How can we identify ictal and interictal abnormal activity? Robert Fisher, Helen Scharfman, Marco de Curtis2 How can we translate “epileptiform” activity in vitro into something that is clinically relevant? Uwe Heinemann, Kevin Staley 3 What is the importance of abnormal “background” activity in seizure generation? Richard Staba, Gregory Worrell4 What is a seizure focus? J. Victor Nadler, Dennis Spencer5 What is a seizure network? Very fast oscillations at the interface between normal and epileptic brain Roger Traub, Mark  Cunningham, Miles Whittington 6 What is a seizure network? Long-range network consequences of focal seizures  Hal Blumenfeld 7 Is there any such thing as “generalized” epilepsy?  Gilles van Luijtelaar, Charles Behr, Massimo Avoli Part II Synaptic plasticity 8 Are there really “epileptogenic” mechanisms or only corruptions of “normal” plasticity? Giuliano Avanzini, Patrick Forcelli, Karen Gale9 When and how do seizures kill neurons - and is cell death relevant to epileptogenesis? Raymond Dingledine, Nicholas Varvek,  F. Edward Dudek 10 How is homeostatic plasticity important in epilepsy? John Swann, Jong Rho  11 Is plasticity of GABA ergic mechanisms relevant to epileptogenesis? Helen Scharfman, Amy Brooks-Kayal 12 Do structural changes in GABA neurons give rise to the epileptic state?  Carolyn Houser13 Does mossy fiber sprouting give rise to the epileptic state?  Paul Buckmaster 14 Does brain inflammation mediate pathological outcomes in epilepsy? Annamaria Vezzani, Karen Wilcox 15 Are changes in synaptic function that underlie hyperexcitability responsible for seizure activity? John Jefferys 16 Does epilepsy cause a reversion to immature function? Aristea Galanopoulou, Solomon Moshe17 Are alterations in transmitter receptor and ion channel expression responsible for the epilepsies? Kim Powell, Katarzyna Lukasiuk, Terence O’Brien, Asla Pitkänen Part III Models and methods18 How do we assess the clinical relevance of models of mesial temporal lobe epilepsy? - Stephen Harward, James McNamara 19 How do we make models that are useful in understanding partial epilepsies? - David Prince20 What non-neuronal mechanisms should be studied to understand epileptic seizures? Damir Janigro, Matthew Walker 21 What epilepsy comorbidities are important to model in the laboratory? Clinical perspectives Simon Shorvon22.Understanding epilepsy comorbidities: how can animal models help?  Carl Stafstrom 23 What new modeling approaches will help us identify promising drug treatments? Scott Baraban, Wolfgang Löscher 24 What are the arguments for and against rational therapy for epilepsy? Melissa Barker-Haliski, Graeme Sills, H. Steve White 25 How can advances in epilepsy genetics lead to better treatments and cures? Renzo Guerrini, Jeffrey Noebels26 How might novel technologies such as optogenetics lead to better treatments in epilepsy? Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz, Merab Kokaia.