Neuroinflammation and Neurodegeneration (eBook)

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2014 | 2014
XVII, 600 Seiten
Springer New York (Verlag)
978-1-4939-1071-7 (ISBN)

Lese- und Medienproben

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State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer's disease, Parkinson's disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer's disease, Parkinson's disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Part 1: Mechanisms of Brain Defense and NeuropathogenesisChapter 1: The Blood Brain BarrierVictor Castro, Michal ToborekChapter 2: Immune Cell Trafficking in the Central Nervous SystemBeena John, Christopher A. Hunter, Tajie H. Harris Chapter 3: General Physiology and Pathophysiology of MicrogliaAlexei Verkhratsky, Mami NodaChapter 4: Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases  Gordon P. Meares, Etty N. BenvenisteChapter 5: Oxidative stress, neuroinflammation, and neurodegenerationHui-Ming Gao, Hui Zhou, Jau-Shyong HongChapter 6: Peripheral Neuroimmune Interactions and Neuropathic PainHalina MachelskaPart 2: Neurological Diseases and InflammationChapter 7: Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s DiseaseRebecca A. Wilshusen, R. Lee MosleyChapter 8: Multiple sclerosis: impact on functioning of the blood-brain barrierMark R. Mizee, Gijs Kooij, Helga E. de Vries Chapter 9: Neuroinflammation in Alzheimer’s diseaseVeronika M. Reinisch, Daniela L. Krause, Norbert MüllerChapter 10: Neuroinflammation in Huntington’s DiseaseRoland G. W. Staal, Thomas MöllerChapter 11: Neuroinflammation and immune regulation in ischemic stroke: identification of new pharmacological targetsMario Di Napoli, Craig J. Smith, Stephen J. Hopkins, Aurel Popa-Wagner, Ana Maria Buga, Mark SlevicPart 3: Infectious DiseasesChapter 12: HIV/NeuroAIDSKelly Stauch, Howard S. FoxChapter 13: Herpes Simplex Virus Infections Of The Central Nervous SystemRichard J. WhitleyChapter 14: Congenital Cytomegalovirus DiseaseMark R. SchleissChapter 15: Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous SystemKallol Dutta, Anirban BasuChapter 16: The biology and clinical consequence of infection with the human polyomavirus JCVG. von Geldern, M. J. Barhams, E.O. Major Chapter 17: Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory DiseaseGregory Antell, Michael R. Nonnemacher, Vanessa Pirrone, Brian WigdahlChapter 18: Immunopathogenesis of bacterial meningitisUwe Koedel, Matthias Klein, Hans-Walter PfisterChapter 19: Cerebral MalariaGregory S. Park, Chandy C. JohnPart 4: Drugs of Abuse and NeuroAIDSChapter 20: HIV and Cocaine Interplay in HIV-associated Neurocognitive DisordersHonghong Yao, Crstal Bethel-Brown, Shilpa Buch Chapter 21: Methamphetamine Neurotoxicity and Neuroinflammatory ProcessesNicole A. Northrop, Bryan K. YamamotoChapter 22: Drugs of Abuse and NeuroAIDS: OpiatesThomas J. RogersChapter 23: CannabinoidsPaige S. Katz, Patricia E. MolinaChapter 24: Alcohol and NeurodegenerationYuri Persidsky, Larisa Goffman, Raghava PotulaPart 5: Novel Approaches to TherapyChapter 25: Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic OutcomesJoEllyn M. McMillan, Howard E. GendelmanChapter 26: Immunomodulatory Therapeutics for Neurodegenerative DiseasesDavid J. Graber, William F. HickeyChapter 27: Therapeutic Potential Of CannabinoidsGuy A. Cabral, Melissa Jamerson

Erscheint lt. Verlag 8.7.2014
Zusatzinfo XVII, 600 p. 48 illus., 35 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Technik
Schlagworte Alzheimer's disease • Multiple Sclerosis • Neurodegeneration • Neuroinflammation • Parkinson's Disease • substances of abuse
ISBN-10 1-4939-1071-X / 149391071X
ISBN-13 978-1-4939-1071-7 / 9781493910717
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