Neuropsychopharmacology

'1 Introduction.- Perspectives on Dopamine as a Regulator of Brain Function.- A View of Psychopharmacology, Neuroscience, and the Major Psychoses.- Lithium Is All Right, but ... About Some Misconceptions and Some Recent Findings.- Improvement in the Quality of Sleep: A New Goal in Psychopharmacology.- The Future of Psychopharmacology and Positron Emission Tomography.- 2 Molecular Biology in Neuropsychopharmacology.- Molecular Biological Approaches to Brain Region- and Cell-Specific Molecules.- The ?1-Adrenergic Receptor as a Paradigm of Receptors Coupled to Guanine Nucleotide Binding Proteins.- The Alpha-2 Adrenoceptor Vulnerability Hypothesis of Depression: From the Clonidine Growth Hormone Stimulation Test to the Genes Encoding a Human Alpha-2 Adrenoceptor and Phenylethanolamine N-Methyltransferase.- 3 Molecular Biology in Neurology and Psychiatry.- Genetic Linkage Analysis in Early-Onset Familial Alzheimer's Dementia.- Molecular Genetic Approach in Affective Illness.- Molecular Genetic Studies in Affective Disorders.- 4 Brain Transplants in Neurology and Psychiatry.- Long-Term Changes in Parkinson's Disease Patients with Adrenal Medullary Autografts to the Caudate Nucleus.- 5 Peripheral Cells as Pharmacological Models in Psychiatric Research.- Lymphocyte Cholinergic Receptor Changes in Alzheimer's Disease.- Increased Platelet Membrane Fluidity in Alzheimer's Disease: An Initial Assessment of Specificity.- [3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders.- Platelet Binding Sites for Serotonin Uptake Inhibitors: Is [3H]Imipramine Binding Decreased in Depression?.- Changes in Platelet Serotonergic and Adrenergic Function in Patients with Depression, Panic Attack, and Mania.- Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment.- 6 Endogenous Ligands for Psychotropic Drug Receptors.- Endogenous Opioids and Motivational Processes: Examination of the Neural Substrates Mediating Opioid-Induced Reward and Aversion.- 7 Biological Markers of Affective Disorders: Impact of Basic Neuroendocrine and Sleep Research.- Sleep-Physiological Characteristics as Potential Biological Markers in Affective Disorders.- Experimental Approaches for Testing the Cholinergic-Noradrenergic Imbalance Hypothesis of Affective Disorders.- Cortisol Response to Corticotropin Releasing Hormone in Dexamethasone-Pretreated Patients with Depression.- Differential Effects and Receptors of Corticosteroids in the Brain: Implications for Psychopathophysiology.- Neuropeptides and Affective Disorder.- Molecular Mechanisms Controlling Proopiomelanocortin Gene Expression.- 8 ?-Adrenoreceptors in Depression and for Antidepressant Effect.- Antidepressant Drugs Given Repeatedly and ?1-Adrenoceptors.- The Effect of Phenylethanolamine-N-Methyltransferase Inhibitor on Locomotor Activity in Rats: The Role of Central ?2-Adrenoceptor and PNMT Activity.- Neuroendocrine Studies of ?2-Adrenoceptor Function and the Mechanism of Action of Antidepressant Drugs.- Levoprotiline: Clinical Therapeutic Efficacy and Tolerability.- ?2-Adrenoceptor Interaction with Opiate Receptors.- Influence of Psychotropic Drugs on Pituitary Hormone Secretion with Special Reference to Norepinephrine Reuptake Inhibition.- 9 The Thyroid Axis in Basic and Clinical Research.- The TRH Test in Psychiatric Disorders.- The Blunted TSH Response to TRH - What Does it Tell Us? Biological Monitoring During Psychopharmacological Treatment.- Alcoholism and the Thyroid Axis.- Marginal Hypothyroidism in Mental Illness: Preliminary Assessments of Prevalence and Significance.- Antithyroid Antibodies: Behavioral Significance.- The Simultaneous Use of Four Releasing Factors: Theoretical and Practical Issues.- 10 PET Imaging in Neurosciences and Psychiatry.- Strategies for In Vivo Quantification of Human Neuroreceptors by Positron Emission Tomography.- Positron Emission Tomography with [18F]Deoxy