Genetics: from Genes to Genomes

Mendel's breakthrough - patterns, particles, and principles of heredity; extension to Mendel for single-gene inheritance; the chromosome theory of inheritance; linkage, recombination, and the mapping of genes on chromosomes; DNA - how the molecule of heredity carries, replicates, and recombines information; anatomy and function of a gene - dissection through mutation; gene expression - the flow of genetic information from DNA via RNA to protein; DNA at high resolution - use of DNA cloning, PCR, and hybridization as the tools of genetic analysis; the direct detection of genotype; the mapping and analysis of genomes; the eukaryotic chromosome - an organelle for packaging and managing DNA; chromosomal rearrangements and changes in chromosome number reshape eukaryotic genomes; the prokaryotic chromosome - genetic analysis in bacteria; the chromosomes of organelles outside the nucleus exhibit non-Mendelian patterns of inheritance; gene regulation in prokaryotes; gene regulation in eukaryotes; cell-cycle regulation and the genetics of cancer; saccharomyces cerevisiae - a genetic portrait of yeast; arabidopsis thaliana - genetic portrait of a model plant; caenorhabditis elegans - genetic portrait of a simple multicellular animal; drosophila melanogaster - genetic portrait of the fruit fly; mus musculus - a genetic portrait of the house mouse; the genetic analysis of populations and how they evolve; evolution at the molecular level.