Mutant p53 and MDM2 in Cancer

p53 and hereditary cancer.- Alterations of p63 and p73 in human cancers.- Cooperation of p53 mutations with other oncogenic alterations in cancer.- p53 mutations and how mutations affect transcription.- Transcriptional regulation by mutant p53 and oncogenesis.- p53 mutation in the genesis of metastasis.- Structural studies on mechanisms to activate mutant p53.- Mutant p53 and the response to chemotherapy and radiation.- The p53-MDM2 loop: a critical juncture of stress response.- Mechanisms of mutant p53 stabilization in cancer.- Crosstalk between Mdm2, p53 and HIF-1α: distinct responses to oxygen stress and implications for tumour hypoxia.- MDM2 overexpression, activation of signaling networks, and cell proliferation.- p53-independent effects of MDM2.- Splice variants of MDM2 in oncogenesis.- MDM2 and MDMX involvement in human cancer.- Targeting the p53-MDM2- MDMX loop for cancer therapy.- Involvement of p53 in the repair of DNA double strand breaks: Multifaceted roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ).- The role of tumor suppressor p53 in the antioxidant defense and metabolism.- Lung cancer stem cells, p53 mutations and MDM2.