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Inflammation in Parkinson's Disease

Scientific and Clinical Aspects

Madhavi Thomas (Herausgeber)

Buch | Hardcover

XVI, 222 Seiten

2014 | 2014
Springer International Publishing (Verlag)
978-3-319-08045-1 (ISBN)

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Parkinson's Disease (PD) is a progressive neurodegenerative disease with a prevalence of 0.1% of the global population, and 5-10% patients are under 40 years of age. Several text books have been published on various aspects of PD to date, including research and clinical aspects. However these do not emphasize the inflammatory pathways and pathways of neurodegeneration in PD. Inflammation in Parkinson's Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation.

Madhavi Thomas is currently a Neurologist and the President of the North Texas Movement Disorders Institute in Colleyville, TX. She continues to serve as the Dallas Chapter of the American Parkinson Disease Association's Medical Director and has held faculty positions at Baylor University and UT Southwestern Medical School.

1. Parkinson's Disease: An Overview of Etiology, Clinical Manifestations, and Treatment . - 2. Neuropathology of Parkinson's Disease. - 3. Role of the Innate and Adaptive Immune System in the Pathogenesis of PD. - 4. "Good" and "Bad" Microglia in Parkinson's Disease: An Understanding of Homeostatic Mechanisms in Immunomodulation . - 5. The Role of Astrocytes in Parkinson's Disease. - 6. Proinflammatory Chemical Signaling: Cytokines. - 7. Cell Culture Models of Inflammation in Parkinson's Disease. - 8. Clinical Aspects of Inflammation in Parkinson's Disease . - 9. PET Imaging in Neuroinflammation.

"This is an excellent monograph about inflammatory mechanics of PD. ... this is an excellent book for neurologists, neurosurgeons, residents, and medical students. Neuromuscular and Stereotactic Fellows will also like this book." (Joseph J. Grenier, Amazon.com, March, 2016)

Erscheint lt. Verlag	11.9.2014
Zusatzinfo	XVI, 222 p. 17 illus., 13 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	526 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	Biologic markers, PET imaging, neuroinflammation, • Cytokine, nitric oxide, anti-inflammatories, anima • Cytokine, nitric oxide, anti-inflammatories, animal models • Neurodegeneration, microglia, oligodendrocytes, as • Neurodegeneration, microglia, oligodendrocytes, astrocytes, • Neuropathology, acute and chronic inflammation, • Parkinson's disease, inflammation, translational n • Parkinson's disease, inflammation, translational neurobiology • Pathologic findings, MPTP toxicity, epidemiology
ISBN-10	3-319-08045-8 / 3319080458
ISBN-13	978-3-319-08045-1 / 9783319080451
Zustand	Neuware