The Basis of Toxicity Testing

Discusses fundamental principles and concepts behind toxicological tests, their design and implementation, interpretation of results, and significance of individual studies in the overall assessment of toxicants.

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This book discusses fundamental principles and concepts behind toxicological tests, their design and implementation, interpretation of results, and significance of individual studies in the overall assessment of toxicants. It covers the complete spectrum of toxicological investigations required for the registration of a chemical (including in vivo and in vitro studies); describes the design of toxicological studies in simple terms, reinforced with diagrams of their design, possible results, and interpretation; examines the various factors that can affect the outcome of a toxicological study; and discusses the limitations of various toxicological tests and their significance in the overall process of hazard and risk evaluation. The book is intended for researchers in toxicology, pharmacology, industrial hygiene, occupational health, nutrition, animal studies, food technology and pesticides.