Autoimmune Disease Models (eBook)

Irun R. Cohen, Ariel Miller (Herausgeber)

eBook Download: PDF | EPUB

2014 | 1. Auflage
329 Seiten
Elsevier Science (Verlag)
978-0-08-091736-8 (ISBN)

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.

Front Cover 1
Autoimmune Disease Models: A
4
Copyright Page 5
Table of
6
Contributors 14
Preface 18
Chapter 1. Experimental Autoimmune Encephalomyelitis
20
I. Introduction: Murine Experimental Autoimmune Encephalomyelitis as a Model for T-CelI-Mediated Demyelinating Disease of the Central Nervous System 20
II. Models of EAE in the Mouse 21
III. Evaluation of the Disease 25
IV. Summary 31
Acknowledgment 32
References 32
Chapter 2. Rat Experimental Autoimmune
34
I. History and Introduction 34
II. Animals and Housing 35
III. Genetic Background 35
IV. Disease Induction 36
V. Quantitation 38
VI. Expert Experience 39
References 40
Chapter 3. Theiler's Virus-Induced
42
I. History and Relevance of the Model 42
II. The Animals 44
III. Genetics of Susceptibility or Resistance 44
IV. The Disease 46
V. Lessons 55
References 55
Chapter 4. Experimental Autoimmune Neuritis 58
I. Introduction 58
II. Isolation and Composition of Peripheral Nerve Myelin 59
III. Basic Features of EAN 60
IV. Immunopathogenesis of EAN—A Model for Therapeutic Studies 71
References 72
Chapter 5. Experimental Autoimmune
76
I. Introduction 76
II. Rat EAU 79
III. Mouse EAU 87
IV. Expert Experience 94
V. Lessons 96
References 96
Chapter 6. Experimental Autoimmune
102
I. Introduction 102
II. Immunization against Purified Electric Organ AChR 104
III. Assessment of EAMG and the Safety Factor 108
IV. Immunization against Purified Mammalian AChR 109
V. Immunization without Adjuvant 109
VI. Genetics of EAMG in Rats and Mice 111
VII. T- and B-Cell Epitopes in EAMG 114
VIII. Immunization against Denatured AChR Subunits, Recombinant or Synthetic Peptides 116
IX. Resistance to EAMG 116
X. Alternative Models 118
XI. Use of EAMG for Therapeutic Studies 120
XII. Relation to Human Disease 120
XIII. Conclusions 120
XIV. Lambert-Eaton Myasthenic Syndrome 122
References 122
Chapter 7. The Obese Strain of Chickens with Spontaneous Autoimmune Thyroiditis as a Model for Hashimoto Disease 126
I. Introduction 126
II. History and Development of the OS 127
III. Clinical Symptoms and Pathohistology 128
IV. Immunological Parameters 129
V. Breeding and Management of OS Chickens 135
VI. Immunogenetics 137
VII. Comparison of SAT and EAT 138
VIII. Use of the OS for the Development of New
139
IX. Conclusions 140
Acknowledgments 140
References 140
Chapter 8. Experimental Autoimmune Thyroiditis in the Mouse and Rat 142
I. Experimental Autoimmune Thyroiditis in the Mouse 142
II. Experimental Autoimmune Thyroiditis in the Rat 152
III. Lessons 157
Acknowledgments 161
References 161
Chapter 9. The NOD Mouse: A Model
166
I. History of the Model 166
II. The Animal 167
III. The Disease 168
IV. Genetics 173
V. Treatment and Prevention 175
VI. Notes for the Beginner 177
VII. What the Model Has Taught Us about Human IDDM 178
References 178
Chapter 10.
182
I. History 182
II. Animals 182
III. Genetics 185
IV. The Disease 186
IV. Quantitation 190
V.
190
VI. Expert Experience 191
VII. Lessons 191
References 192
Chapter 11.
194
I. The Models 194
II. Production of Virus-Induced Myocarditis 196
III. Production of Myosin-lnduced Myocarditis 200
IV. Evaluation 201
Acknowledgment 207
References 207
Chapter 12.
210
I. History of Experimental Autoimmune Hepatitis 210
II. Animals 212
III. Genetic Background 212
IV. Induction and Time Course 212
V. Quantitation 215
VI. Resistance 216
VII. Expert Experience 216
VIII. Lessons 217
References 217
Chapter 13.
220
I. History of the Model 220
II. Animals 221
III. Induction of the Disease 222
IV. Course of the Disease 227
V. Quantitation of the Disease 228
VI. Resistance to the Disease 230
VII. Expert Experience 231
VIII. Lessons 232
Acknowledgment 233
References 233
Chapter 14. Murine Models of Spontaneous Systemic Lupus Erythematosus 236
I. Introduction 236
II. (NZB x NZW)
237
III. MRL-lpr/lpr 244
IV. Quantitation 255
V. Conclusions 259
Acknowledgment 259
References 259
Chapter 15. Experimental Systemic Lupus Erythematosus: Role of the Idiotypic Network 264
I. History of the Model 264
II. Animals and Housing 266
III. Genetic Background 267
IV. Disease Induction 268
V. Course of the Disease 269
VI. Resistance to the Disease 270
VII. Manipulation of the Disease 271
VIII. Lessons 272
Acknowledgment 272
References 272
Chapter 16.
276
I. Introduction and History of the Model 276
II. Animals 276
III. Genetic Background 277
IV. Disease Induction 277
V. Lesion and Course of the Disease 278
VI. Autoimmune Myositis 283
References 283
Chapter 17. Testicular and Ovarian Autoimmune Diseases 286
I. Introduction 286
II. Experimental Autoimmune Orchitis 287
III. Experimental Autoimmune Oophoritis 294
IV. Autoimmune Oophoritis Following Manipulation of the
299
V. Summary and Conclusions 306
Acknowledgments 307
References 307
Chapter 18.
310
I. Chronic Graft-versus-Host Disease 310
II. Host-versus-Graft Disease 314
III. Lessons 318
References 319
Chapter 19. Assessment of Discomfort in
322
I. Introduction 322
II. Arguments for Assessing Discomfort 323
III. Stress and Discomfort 324
IV. Assessment of Discomfort 330
V. An Example of Assessing Discomfort in Practice 333
VI. Possibilities for Diminishing Discomfort 335
References 337
Index 340

Contributors

Numbers in parentheses indicate the pages on which the authors’ contributions begin.

Ahmad Al-Sabbagh, (15) Center for Neurologic Diseases, Brigham and Womens Hospital, and Harvard Medical School, Boston, Massachusetts 02115

V. Baumans, (303) Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, 3508 TD Utrecht, The Netherlands

Stefan Brocke, (1) Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305

Karl-Hermann Meyer zum Büschenfelde, (191) Department of Medicine, Johannes Gutenberg-University, D-6500 Mainz, Germany

Rachel R. Caspi, (57) Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892

R. Cole, (107) New York State College of Agriculture and Life Sciences, Department of Poultry and Avian Sciences, Cornell University, Ithaca, New York 14853

Mauro C. Dal Canto, (23) Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

S.F. de Boer, (303) Department of Animal Physiology, University of Groningen, 9750 AA Haren, The Netherlands

H. Dietrich, (107) Institute for General and Experimental Pathology, University of Innsbruck Medical School, 6020 Innsbruck, Austria

Dana Elias, (147) Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel

Zsuzsanna Fabry, (257) Department of Pathology, Division of Neuropathology, University of Iowa, College of Medicine, Iowa City, Iowa 52242

Sandrine Florquin, (291) Laboratoire Pluridisciplinaire de Recherche Experimentale Biomédicale et Service d’Immunologie, Hôpital Erasme, Université Libre de Bruxelles, B-1070 Brussels, Belgium

Koenraad Gijbels, (1) Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305

Alvaro A. Giraldo, (123) Division of Immunopathology, St. John Hospital, Detroit, Michigan 48236

Michel Goldman, (291) Laboratoire Pluridisciplinaire de Recherche Experimentale Biomédicale et Service d’Immunologie, Hôpital Erasme, Université Libre de Bruxelles, B-1070 Brussels, Belgium

Peter A. Gottlieb, (163) Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655

K. Hála, (107) Institute for General and Experimental Pathology, University of Innsbruck Medical School, 6020 Innsbruck, Austria

Michael N. Hart, (257) Department of Pathology, Division of Neuropathology, University of Iowa, College of Medicine, Iowa City, Iowa 52242

Susan L. Hill, (175) Department of Immunology and Infectious Diseases, The Johns Hopkins University, Baltimore, Maryland 21205

William J. Karpus, (23) Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611

Yi-chi M. Kong, (123) Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201

Christopher Linington, (39) Max-Planck-Institute of Psychiatry, D-82152 Martinsried, Germany

Ansgar W. Lohse, (191) Department of Medicine, Johannes Gutenberg-University, D-6500 Mainz, Germany

Ch. Maczek, (107) Institute for General and Experimental Pathology, University of Innsbruck, Medical School, 6020 Innsbruck, Austria

Roger W. Melvold, (23) Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611

Stephen D. Miller, (23) Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611

Edna Mozes, (245) Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel

P.-U. Müller, (107) Institute for General and Experimental Pathology, University of Innsbruck Medical School, 6020 Innsbruck, Austria

Yaakov Naparstek, (217) The Clinical Immunology and Allergy Unit, Department of Medicine, Hadassah University Hospital, Jerusalem 91120, Israel

David A. Neumann, (175) Risk Science Institute, International Life Sciences Institute, Washington DC 20036

Jonathan G. Pope, (23) Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Ilinois 60611

Chaim Putterman, (217) The Clinical Immunology and Allergy Unit, Department of Medicine, Hadassah University Hsopital, Jerusalem 91120, Israel, and the Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461

Noel R. Rose, (175) Department of Immunology and Infectious Diseases, The Johns Hopkins University, Baltimore, Maryland 21205

Aldo A. Rossini, (163) Division of Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655

Yehuda Shoenfeld, (245) Research Unit of Autoimmune Diseases, Department of Medicine ‘B,’ Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Hashomer 52621, Israel

Lawrence Steinman, (1) Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305

Osamu Taguchi, (267) Aichi Cancer Center Research Institute, Nagoya 464, Japan

Cory Teuscher, (291) Department of Microbiology, Brigham Young University, Provo, Utah 84602

Kenneth S.K. Tung, (267) Department of Pathology, University of Virginia, Charlottesville, Virginia 22906

Willem van Eden, (201) Utrecht University, Faculty of Veterinary Science, Institute of Infectious Diseases and Immunology, Department of Immunology, Utrecht, The Netherlands

H. van Herck, (303) Central Laboratory Animal Institute (GDL), Utrecht University, 3508 TD Utrecht, The Netherlands

Angela Vincent, (83) Neurosciences Group, Department of Clinical Neurology, Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DU, United Kingdom

Josée P.A. Wagenaar-Hilbers, (201) Utrecht University, Faculty of Veterinary Science, Institute of Infectious Diseases and Immunology, Department of Immunology, Utrecht, The Netherlands

Marca H.M. Wauben, (201) Utrecht University, Faculty of Veterinary Science, Institute of Infectious Diseases and Immunology, Department of Immunology, Utrecht, The Netherlands

Howard L....

Erscheint lt. Verlag	28.6.2014
Sprache	englisch
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	0-08-091736-4 / 0080917364
ISBN-13	978-0-08-091736-8 / 9780080917368

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