Pharmacokinetic Challenges in Drug Discovery

1 Accelerating the Process of Drug Discovery.- 2 The Role of Pharmacokinetics in Drug Discovery: Finding Drug Candidates with the Greatest Potential for Success.- 3 Rapid Permeability Screening in Drug Discovery to Predict Human Intestinal Absorption.- 4 Drug Metabolism Assays and Their Use in Drug Discovery.- 5 Prediction of Human Pharmacokinetics Based on Preclinical In Vitro and In Vivo Data.- 6 In Vitro Screening of Cytochrome P450 Induction Potential.- 7 Drug Transport Across the Blood-Brain Barrier.- 8 The Development and Implementation of Bioanalytical Methods Using LC-MS to Support ADME Studies in Early Drug Discovery and Candidate Selection.- 9 Strategies in Lead Selection and Optimization: Application of a Graphical Model and Automated In Vitro ADME Screening.- 10 High-Throughput Screening - Brains Versus Brawn.- 11 Relation of Molecular Properties with Drug Absorption and Disposition.- 12 Modelling Human Cytochrome P450-Substrate Interactions.- 13 Forum Discussion.- Previous Volumes Published in This Series.