Cancer Gene Therapy by Viral and Non-viral Vectors (eBook)

Provides expert, state-of-the-art insight into the current
progress of viral and non-viral gene therapy

Translational medicine has opened the gateway to the era of
personalized or precision medicine. No longer a one-size-fits-all
approach, the treatment of cancer is now based on an understanding
of underlying biologic mechanisms and is increasingly being
tailored to the molecular specificity of a tumor.

This book provides a comprehensive overview of the pertinent
molecular discoveries in the cancer field and explains how these
are being used for gene-based cancer therapies. Designed as a
volume in the Translational Oncology book series, Cancer Gene
Therapy by Viral and Non-viral Vectors deals with the practice
of gene-therapy, with reference to vectors for gene expression and
gene transfer, as well as viral therapy. It covers the history and
current and future applications of gene transfer in cancer, and
provides expert insight on the progress of viral and non-viral gene
therapy with regard to delivery system, vector design, potential
therapeutic genes, and principles and regulations for cancer gene
therapy.

Presented in three parts, Cancer Gene Therapy by Viral and
Non-viral Vectors covers:

Delivery Systems

* Translational Cancer Research: Gene Therapy by Viral
and Non-viral Vectors

* Retroviruses for Cancer Therapy

* DNA Plasmids for Non-viral Gene Therapy of
Cancer

* Cancer Therapy with RNAi delivered by Non-viral
Membrane/Core Nanoparticles

Targeted Expression

* Cancer Gene Therapy by Tissue-specific and
Cancer-targeting Promptors

* MicroRNAs as Drugs and Drug Targets in Cancer

Principles of Clinical Trials in Gene Therapy

* Regulatory issues for Manufacturers of Viral Vectors
and Vector-transduced Cells for Phase I/II Trials

* US Regulations Governing Clinical Trials in Gene
Therapy

* Remaining Obstacles to the Success of Cancer Gene
Therapy

Focusing on speeding the process in clinical cancer care by
bringing therapies as quickly as possible from bench to bedside,
Cancer Gene Therapy by Viral and Non-viral Vectors is an
absolutely vital book for physicians, clinicians, researchers, and
students involved in this area of medicine.